Literature DB >> 3080808

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

R J D'Amato, Z P Lipman, S H Snyder.   

Abstract

Methylphenyltetrahydropyridine (MPTP) selectively destroys neuronal cell bodies in the melanin-containing substantia nigra of humans and other primates. We show that methylphenylpyridine (MPP+), an active metabolite of MPTP which is accumulated intraneuronally by the catecholamine uptake system, binds with high affinity to melanin and neuromelanin. MPP+ bound intracellularly to neuromelanin may be released gradually, resulting in subsequent damage to the neurons of the substantia nigra.

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Year:  1986        PMID： 3080808     DOI： 10.1126/science.3080808

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  43 in total

1.  In vivo distribution of catecholamine reuptake sites in human brain gives clues to the physiopathology of MPTP-induced parkinsonism.

Authors:  E Salmon; D J Brooks
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-02       Impact factor: 10.154

2.  Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.

Authors:  F A Zucca; C Bellei; S Giannelli; M R Terreni; M Gallorini; E Rizzio; G Pezzoli; A Albertini; L Zecca
Journal:  J Neural Transm (Vienna)       Date:  2006-04-28       Impact factor: 3.575

3.  The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.

Authors:  William D Bush; Jacob Garguilo; Fabio A Zucca; Alberto Albertini; Luigi Zecca; Glenn S Edwards; Robert J Nemanich; John D Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-25       Impact factor: 11.205

Review 4.  Neuromelanin of the human substantia nigra: an update.

Authors:  Fabio A Zucca; Emy Basso; Francesca A Cupaioli; Emanuele Ferrari; David Sulzer; Luigi Casella; Luigi Zecca
Journal:  Neurotox Res       Date:  2013-10-24       Impact factor: 3.911

5.  Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+.

Authors:  C J Sun; J N Johannessen; W Gessner; I Namura; W Singhaniyom; A Brossi; C C Chiueh
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

Review 6.  Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson's disease.

Authors:  Gunasingh J Masilamoni; Yoland Smith
Journal:  J Neural Transm (Vienna)       Date:  2017-08-31       Impact factor: 3.575

7.  Saturation Binding of Nicotine to Synthetic Neuromelanin Demonstrated by Fluorescence Spectroscopy.

Authors:  Robert L Haining; Travis M Jones; Aubrey Hernandez
Journal:  Neurochem Res       Date:  2016-09-23       Impact factor: 3.996

8.  Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Authors:  F Solano; V J Hearing; J C García-Borrón
Journal:  Neurotox Res       Date:  2000-02       Impact factor: 3.911

9.  Intraneuronal dopamine-quinone synthesis: a review.

Authors:  D Sulzer; L Zecca
Journal:  Neurotox Res       Date:  2000-02       Impact factor: 3.911

10.  New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals.

Authors:  Luigi Zecca; Chiara Bellei; Patrizia Costi; Alberto Albertini; Enrico Monzani; Luigi Casella; Mario Gallorini; Luigi Bergamaschi; Alberto Moscatelli; Nicholas J Turro; Melvin Eisner; Pier Raimondo Crippa; Shosuke Ito; Kazumasa Wakamatsu; William D Bush; Weslyn C Ward; John D Simon; Fabio A Zucca
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-06       Impact factor: 11.205
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