Literature DB >> 3080807

Detection of alpha-transducin in retinal rods but not cones.

G B Grunwald, P Gierschik, M Nirenberg, A Spiegel.   

Abstract

The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.

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Year:  1986        PMID： 3080807     DOI： 10.1126/science.3080807

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.

Authors:  P D Calvert; N V Krasnoperova; A L Lyubarsky; T Isayama; M Nicoló; B Kosaras; G Wong; K S Gannon; R F Margolskee; R L Sidman; E N Pugh; C L Makino; J Lem
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

Review 2.  Pharmacological and molecular basis for dopamine D-2 receptor diversity.

Authors:  M Memo
Journal:  Mol Neurobiol       Date:  1990 Fall-Winter       Impact factor: 5.590

Review 3.  Cyclic nucleotides and retinal cones.

Authors:  A I Cohen
Journal:  Neurochem Res       Date:  1987-06       Impact factor: 3.996

4.  Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction.

Authors:  E R Weiss; M H Ducceschi; T J Horner; A Li; C M Craft; S Osawa
Journal:  J Neurosci       Date:  2001-12-01       Impact factor: 6.167

5.  Reduced level of interphotoreceptor retinoid-binding protein (IRBP), a possible cause for retinal degeneration in the Abyssinian cat.

Authors:  K Narfström; S E Nilsson; B Wiggert; L Lee; G J Chader; T van Veen
Journal:  Cell Tissue Res       Date:  1989-09       Impact factor: 5.249

6.  Expression of GTP-binding protein alpha subunits in human thymocytes.

Authors:  P S Kabouridis; S T Waters; S Escobar; J Stanners; C D Tsoukas
Journal:  Mol Cell Biochem       Date:  1995-03-09       Impact factor: 3.396

7.  Human cDNA clones for an alpha subunit of Gi signal-transduction protein.

Authors:  P Bray; A Carter; V Guo; C Puckett; J Kamholz; A Spiegel; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Assignment of groups responsible for the "opsin shift" and light absorptions of rhodopsin and red, green, and blue iodopsins (cone pigments).

Authors:  E M Kosower
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205
  8 in total

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