Literature DB >> 30807998

Sweet and CRISP(R)y parasite engineering.

Iain B H Wilson1, Irma Schabussova2.   

Abstract

Toxoplasma gondii is an intracellular parasite that is highly prevalent within human populations. Its genome encodes a range of enzymes involved in glycan biosynthesis and metabolism. A new study presents a library of CRISPR/Cas9-based glyco-relevant gene knockouts and their examination in glycomic and functional assays. This new resource can pave the way for a better understanding of the role of carbohydrates in infection and immunomodulation by this significant protozoan parasite.
© 2019 Wilson and Schabussova.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30807998      PMCID： PMC6349113          DOI： 10.1074/jbc.H118.007210

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  7 in total

1.  Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.

Authors:  Sachin Khurana; Michael J Coffey; Alan John; Alessandro D Uboldi; My-Hang Huynh; Rebecca J Stewart; Vern B Carruthers; Christopher J Tonkin; Ethan D Goddard-Borger; Nichollas E Scott
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157

2.  O-Fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites.

Authors:  Giulia Bandini; Deborah R Leon; Carolin M Hoppe; Yue Zhang; Carolina Agop-Nersesian; Melanie J Shears; Lara K Mahal; Françoise H Routier; Catherine E Costello; John Samuelson
Journal:  J Biol Chem       Date:  2018-12-11       Impact factor: 5.157

3.  CRISPR/Cas9 and glycomics tools for Toxoplasma glycobiology.

Authors:  Elisabet Gas-Pascual; Hiroshi Travis Ichikawa; Mohammed Osman Sheikh; Mariam Isabella Serji; Bowen Deng; Msano Mandalasi; Giulia Bandini; John Samuelson; Lance Wells; Christopher M West
Journal:  J Biol Chem       Date:  2018-11-21       Impact factor: 5.157

4.  Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

Authors:  Kazi Rahman; Msano Mandalasi; Peng Zhao; M Osman Sheikh; Rahil Taujale; Hyun W Kim; Hanke van der Wel; Khushi Matta; Natarajan Kannan; John N Glushka; Lance Wells; Christopher M West
Journal:  J Biol Chem       Date:  2017-09-19       Impact factor: 5.157

5.  Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study.

Authors:  P M Matricardi; F Rosmini; S Riondino; M Fortini; L Ferrigno; M Rapicetta; S Bonini
Journal:  BMJ       Date:  2000-02-12

6.  Immunoregulation by Toxoplasma gondii infection prevents allergic immune responses in mice.

Authors:  Angelika Wagner; Elisabeth Förster-Waldl; Erika Garner-Spitzer; Irma Schabussova; Michael Kundi; Arnold Pollak; Otto Scheiner; Anja Joachim; Ursula Wiedermann
Journal:  Int J Parasitol       Date:  2008-10-02       Impact factor: 3.981

7.  Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation.

Authors:  Mirjana Drinić; Angelika Wagner; Priya Sarate; Christian Zwicker; Elke Korb; Gerhard Loupal; Roman Peschke; Anja Joachim; Ursula Wiedermann; Irma Schabussova
Journal:  Sci Rep       Date:  2017-11-09       Impact factor: 4.379
  7 in total
  1 in total

1.  Reduction of Allergic Lung Disease by Mucosal Application of Toxoplasma gondii-Derived Molecules: Possible Role of Carbohydrates.

Authors:  Elke Korb; Mirjana Drinić; Angelika Wagner; Nora Geissler; Aleksandra Inic-Kanada; Roman Peschke; Anja Joachim; Ursula Wiedermann; Irma Schabussova
Journal:  Front Immunol       Date:  2021-03-10       Impact factor: 7.561
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.