Greta Hill1, Claudia Dehn1, Annette Viktoria Hinze2, Matthias Frentzen3, Jörg Meister4. 1. Department of Periodontology, Operative and Preventive Dentistry, Bonn University, Dental Faculty, 53111 Bonn, Germany. 2. Clinical Study Support Core, University Hospital Bonn, 53015 Bonn, Germany. 3. Department of Periodontology, Operative and Preventive Dentistry, Bonn University, Dental Faculty, 53111 Bonn, Germany. Electronic address: frentzen@uni-bonn.de. 4. Department of Periodontology, Operative and Preventive Dentistry, Bonn University, Dental Faculty, 53111 Bonn, Germany; Center of Applied Medical Laser Research and Biomedical Optics (AMLaReBO), Bonn University, 53111, Germany.
Abstract
BACKGROUND: The objective was to evaluate the efficiency of indocyanine green (ICG)-based adjunctive antimicrobial photodynamic therapy (aPDT) in a prospective clinical study regarding non-surgical treatment of chronic periodontitis. METHODS: Affected teeth of twenty patients were treated with scaling and root planing (control group). Using a split-mouth design, two quadrants received additional ICG-based (perio green®, 0.1mg/ml) aPDT (test group) with a diode laser at 808 nm (100mW at 2 kHz). Clinical assessment of bleeding on probing (BOP), sulcus fluid flow rate (SFFR) and microbiological analysis were performed at baseline, two weeks, three and six months after treatment. Relative attachment level (RAL), probing depths (PD) and gingival recession (GR), were also analyzed. RESULTS: At baseline, none of the assessed parameters showed significant differences between the test and control groups. Median values for BOP, RAL, PD, decreased significantly in both groups after three months of treatment (p ≤ 0.05) without significant difference between the groups. Two weeks after treatment, the SFFR showed significantly lower mean values in the test group (aPDT). CONCLUSION: Within the study limits, the only significant difference between the control group and the aPDT group was a transient smaller amount of SFFR in the latter during the first follow-up. With the applied parameters, this study does not conclusively support ICG-based aPDT, though it is promising because no adverse effects occurred. The precise modes of action of ICG must be elucidated, and further clinical trials are needed.
RCT Entities:
BACKGROUND: The objective was to evaluate the efficiency of indocyanine green (ICG)-based adjunctive antimicrobial photodynamic therapy (aPDT) in a prospective clinical study regarding non-surgical treatment of chronic periodontitis. METHODS: Affected teeth of twenty patients were treated with scaling and root planing (control group). Using a split-mouth design, two quadrants received additional ICG-based (perio green®, 0.1 mg/ml) aPDT (test group) with a diode laser at 808 nm (100 mW at 2 kHz). Clinical assessment of bleeding on probing (BOP), sulcus fluid flow rate (SFFR) and microbiological analysis were performed at baseline, two weeks, three and six months after treatment. Relative attachment level (RAL), probing depths (PD) and gingival recession (GR), were also analyzed. RESULTS: At baseline, none of the assessed parameters showed significant differences between the test and control groups. Median values for BOP, RAL, PD, decreased significantly in both groups after three months of treatment (p ≤ 0.05) without significant difference between the groups. Two weeks after treatment, the SFFR showed significantly lower mean values in the test group (aPDT). CONCLUSION: Within the study limits, the only significant difference between the control group and the aPDT group was a transient smaller amount of SFFR in the latter during the first follow-up. With the applied parameters, this study does not conclusively support ICG-based aPDT, though it is promising because no adverse effects occurred. The precise modes of action of ICG must be elucidated, and further clinical trials are needed.
Authors: Sakari Nikinmaa; Niina Moilanen; Timo Sorsa; Juha Rantala; Heikki Alapulli; Anja Kotiranta; Petri Auvinen; Esko Kankuri; Jukka H Meurman; Tommi Pätilä Journal: Dent J (Basel) Date: 2021-05-03