Joanna Katarzynska1, Anna Borkowska2, Przemyslaw Czajkowski3, Agnieszka Los2, Lukasz Szczerbinski4, Agnieszka Milewska-Kranc5, Andrzej Marcinek6, Adam Kretowski7, Katarzyna Cypryk2, Jerzy Gebicki8. 1. Angionica Ltd., Lodz, Poland. 2. Department of Internal Diseases and Diabetology, Medical University of Lodz, Lodz, Poland. 3. Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland. 4. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. 5. Clinical Service, Warsaw, Poland. 6. Angionica Ltd., Lodz, Poland; Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland. 7. Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland; Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. 8. Angionica Ltd., Lodz, Poland; Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland. Electronic address: jerzy.gebicki@p.lodz.pl.
Abstract
STUDY DESCRIPTION: Flow Mediated Skin Fluorescence (FMSF) is a novel technique for non-invasive evaluation of the microcirculation and metabolic regulation. This study describes the diagnostic potential of FMSF for type 1 diabetes (DM1). STUDY POPULATION: All study participants, in both the control (n = 31) and DM1 (n = 40) groups, were between the ages of 30-49 y. The patients in the DM1 group had all been suffering from diabetes for at least 10 y. RESULTS: The parameters HRindex, HRmax and MR inversely correlate with age and BMI. An unidentified compensatory effect was observed among the younger members of the DM1 group. The majority of DM1 patients with HRindex < 8% showed signs of dysfunctional metabolic regulation. CONCLUSION: FMSF appears to be an extremely useful technique for monitoring diabetic patients over time, enabling early diagnosis of potentially dysfunctional microcirculation and metabolic regulation.
STUDY DESCRIPTION: Flow Mediated Skin Fluorescence (FMSF) is a novel technique for non-invasive evaluation of the microcirculation and metabolic regulation. This study describes the diagnostic potential of FMSF for type 1 diabetes (DM1). STUDY POPULATION: All study participants, in both the control (n = 31) and DM1 (n = 40) groups, were between the ages of 30-49 y. The patients in the DM1 group had all been suffering from diabetes for at least 10 y. RESULTS: The parameters HRindex, HRmax and MR inversely correlate with age and BMI. An unidentified compensatory effect was observed among the younger members of the DM1 group. The majority of DM1patients with HRindex < 8% showed signs of dysfunctional metabolic regulation. CONCLUSION: FMSF appears to be an extremely useful technique for monitoring diabeticpatients over time, enabling early diagnosis of potentially dysfunctional microcirculation and metabolic regulation.
Authors: Joanna Katarzynska; Anna Borkowska; Agnieszka Los; Andrzej Marcinek; Katarzyna Cypryk; Jerzy Gebicki Journal: J Diabetes Sci Technol Date: 2019-12-19
Authors: Agnieszka Los-Stegienta; Joanna Katarzynska; Anna Borkowska; Andrzej Marcinek; Katarzyna Cypryk; Jerzy Gebicki Journal: Vasc Health Risk Manag Date: 2021-04-19
Authors: Regina Pawlak-Chomicka; Tomasz Krauze; Pawel Uruski; Jaroslaw Piskorski; Andrzej Wykretowicz; Andrzej Tykarski; Przemyslaw Guzik Journal: Cardiol Res Pract Date: 2022-03-31 Impact factor: 1.866
Authors: Michal Chudzik; Anna Cender; Robert Mordaka; Jacek Zielinski; Joanna Katarzynska; Andrzej Marcinek; Jerzy Gebicki Journal: Vasc Health Risk Manag Date: 2022-09-06