Brian S Biesman1, Joel L Cohen2, Barry E DiBernardo3, Jason J Emer4, Roy G Geronemus5, Michael H Gold6, Alayne S Lehman7, Brian K Pilcher8, Gary D Monheit9, Todd E Schlesinger10, Craig F Teller11. 1. Ophthalmology, Dermatology, and Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee. 2. AboutSkin Dermatology and DermSurgery, Greenwood Village, Colorado. 3. New Jersey Plastic Surgery, Montclair, New Jersey. 4. Jason Emer, MD, Beverly Hills, California. 5. Laser & Skin Surgery Center of New York, New York, New York. 6. Tennessee Clinical Research Center, Nashville, Tennessee. 7. Suneva Medical, San Diego, California. 8. Critical Mass Scientific Strategy, Rochester, North Carolina. 9. Total Skin and Beauty Dermatology, Birmingham, Alabama. 10. Dermatology and Laser Center of Charleston, Charleston, South Carolina. 11. Bellaire Dermatology, Bellaire, Texas.
Abstract
BACKGROUND: Microneedling and soft-tissue filler injections have been used independently to improve acne scarring. The effectiveness of a combined approach using microneedling followed by polymethylmethacrylate (PMMA)-collagen gel has not been carefully studied. OBJECTIVE: The goal of this study was to assess the effectiveness and safety of microneedling alone versus microneedling followed by injection of PMMA-collagen gel filler for correction of atrophic facial acne scars. METHODS: We conducted a multicenter, open-label, randomized, prospective study on subjects with distensible atrophic acne scars in the face to determine whether microneedling with PMMA-collagen gel is a superior acne scar treatment over microneedling alone. Forty-four subjects received 3 microneedling treatments over a 12-week period followed by randomization to treatments with PMMA-collagen gel (treatment group) or no further treatment (control group). RESULTS: At 24 weeks, the treatment group achieved a statistically significant improvement in acne scores over microneedling alone. The improvement continued at 36 weeks. At 24 weeks, the treatment group showed a strong trend in improvement on the Physician Global Aesthetic Improvement Scale compared with microneedling alone.
RCT Entities:
BACKGROUND: Microneedling and soft-tissue filler injections have been used independently to improve acne scarring. The effectiveness of a combined approach using microneedling followed by polymethylmethacrylate (PMMA)-collagen gel has not been carefully studied. OBJECTIVE: The goal of this study was to assess the effectiveness and safety of microneedling alone versus microneedling followed by injection of PMMA-collagen gel filler for correction of atrophic facial acne scars. METHODS: We conducted a multicenter, open-label, randomized, prospective study on subjects with distensible atrophic acne scars in the face to determine whether microneedling with PMMA-collagen gel is a superior acne scar treatment over microneedling alone. Forty-four subjects received 3 microneedling treatments over a 12-week period followed by randomization to treatments with PMMA-collagen gel (treatment group) or no further treatment (control group). RESULTS: At 24 weeks, the treatment group achieved a statistically significant improvement in acne scores over microneedling alone. The improvement continued at 36 weeks. At 24 weeks, the treatment group showed a strong trend in improvement on the Physician Global Aesthetic Improvement Scale compared with microneedling alone.
Authors: Galit H Frydman; David Olaleye; Damodaran Annamalai; Kim Layne; Illina Yang; Haytham M A Kaafarani; James G Fox Journal: Sci Rep Date: 2020-08-06 Impact factor: 4.379