Literature DB >> 3080636

Regression of rat primary mammary tumors following dietary d-limonene.

J A Elegbede, C E Elson, M A Tanner, A Qureshi, M N Gould.   

Abstract

The effects of d-limonene on rat mammary tumors were investigated. Following the appearance of mammary tumors induced by 7,12-dimethylbenz[a]anthracene in female (W/Fu X F344)F2 rats, animals were assigned to pairs in which 1 rat was fed a diet containing 10% d-limonene and the other was pair fed an isocaloric diet containing 10% cellulose. There was a highly significant increase in the regression of the first tumors in the rats fed d-limonene. In addition, d-limonene given at this time inhibited the formation of subsequent multiple tumors in these rats.

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Year:  1986        PMID： 3080636

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  16 in total

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8.  Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.

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9.  Human metabolism of the experimental cancer therapeutic agent d-limonene.

Authors:  P L Crowell; C E Elson; H H Bailey; A Elegbede; J D Haag; M N Gould
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Review 10.  Cancer prevention with promising natural products: mechanisms of action and molecular targets.

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