Wojciech Roczniak1, Agata Mikołajczak-Będkowska2, Elżbieta Świętochowska3, Zofia Ostrowska3, Katarzyna Ziora4, Sylwia Balcerowicz5, Karolina Górska-Flak6, Magdalena Milan7, Joanna Oświęcimska4. 1. Institute of Medicine, Jan Grodek State Vocational School in Sanok, Sanok, Poland. 2. Department of Physiology Pathology and Neonatal Intensive Care, Multidisciplinary Hospital, Gliwice, Poland. 3. Molecular Biology, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland. 4. Pediatrics, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland. 5. Department of Pediatric Gastroenterology and Hepatology, University Hospital No 1 in Zabrze Medical University of Silesia in Katowice, Zabrze, Poland. 6. Department of Pediatrics, University Hospital in Opole University of Opole, Opole, Poland. 7. Department of Pediatrics, District Hospital, Strzelce Opolskie, Poland.
Abstract
Background: Interleukin 15 (IL-15) plays a key role in the muscle-fat interaction, reducing adipose tissue mass without changes in the lean body mass and reduction of food intake. Here we assess serum IL-15 levels in girls with anorexia nervosa (AN) relative to obese and normal weight female adolescents. Methods: Serum IL-15 concentrations were evaluated using a commercially available ELISA kit in 32 Polish girls with restrictive AN, 29 girls with obesity (O), and 21 healthy controls (C). Anthropometric measurements (weight, height, BMI) and laboratory assays (serum fasting glucose, insulin, HOMA-IR, total cholesterol, HDL, LDL, triglycerides, and C-reactive protein (CRP)) were performed. Results: Mean serum IL-15 in the AN group was significantly higher than in C, but lower than in O. In all examined girls, significant positive correlations between IL-15 and body weight, BMI, insulin, HOMA, LDL, triglycerides and CRP were noted. We also observed an inverse relationship between IL-15 and HDL.Conclusions: Our study demonstrated that serum IL-15 concentrations in adolescent girls with AN and obesity are significantly elevated in comparison to normal weight controls. However, the role of IL-15 in the pathogenesis of AN and obesity remains still unclear.
Background: Interleukin 15 (IL-15) plays a key role in the muscle-fat interaction, reducing adipose tissue mass without changes in the lean body mass and reduction of food intake. Here we assess serum IL-15 levels in girls with anorexia nervosa (AN) relative to obese and normal weight female adolescents. Methods: Serum IL-15 concentrations were evaluated using a commercially available ELISA kit in 32 Polish girls with restrictive AN, 29 girls with obesity (O), and 21 healthy controls (C). Anthropometric measurements (weight, height, BMI) and laboratory assays (serum fasting glucose, insulin, HOMA-IR, total cholesterol, HDL, LDL, triglycerides, and C-reactive protein (CRP)) were performed. Results: Mean serum IL-15 in the AN group was significantly higher than in C, but lower than in O. In all examined girls, significant positive correlations between IL-15 and body weight, BMI, insulin, HOMA, LDL, triglycerides and CRP were noted. We also observed an inverse relationship between IL-15 and HDL.Conclusions: Our study demonstrated that serum IL-15 concentrations in adolescent girls with AN and obesity are significantly elevated in comparison to normal weight controls. However, the role of IL-15 in the pathogenesis of AN and obesity remains still unclear.
Entities:
Keywords:
Anorexia nervosa; body mass index; insulin resistance; interleukin 15; paediatric obesity
Authors: Saúl Ramírez-De Los Santos; Edgar Iván López-Pulido; Isabel Del Carmen Medrano-González; Julieta Saraí Becerra-Ruiz; Carmen Celina Alonso-Sanchez; Sonia Isela Vázquez-Jiménez; Celia Guerrero-Velázquez; Juan Manuel Guzmán-Flores Journal: Odontology Date: 2020-04-13 Impact factor: 2.634
Authors: Hannah E Specht; Nina Mannig; Meriem Belheouane; Nadia Andrea Andreani; Klaus Tenbrock; Ronald Biemann; Katrin Borucki; Brigitte Dahmen; Astrid Dempfle; John F Baines; Beate Herpertz-Dahlmann; Jochen Seitz Journal: Front Psychiatry Date: 2022-08-18 Impact factor: 5.435
Authors: Nikola Sekaninova; Lucia Bona Olexova; Zuzana Visnovcova; Igor Ondrejka; Ingrid Tonhajzerova Journal: Int J Mol Sci Date: 2020-10-02 Impact factor: 5.923