Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR, MLR and PLR in non-affective psychosis. Methods: Eight studies have been identified from the main electronic databases. Meta-analyses based on random-effects models have been carried out generating pooled standardised mean differences (SMDs) between non-affective psychotic patients and healthy controls (HCs). Results: Subjects with non-affective psychosis had a significant higher NLR and MLR as compared with HC (respectively SMD = 0.715; P < 0.001; I2=57.565% and SMD = 0.417; P = 0.001; I2=65.754%), confirmed by heterogeneity-based sensitivity analysis. Subgroup analyses showed no differences in effect size across different study characteristics, including drug treatment status, diagnosis, and setting. Meta-regression showed that age influenced the relationship between non-affective psychosis and MLR. A trend of significance, not confirmed by heterogeneity-based sensitivity analysis, was observed in PLR with patients showing higher PLR than HC.Conclusions: Our meta-analysis supports the hypothesis that an inflammatory activation occurs in non-affective psychosis and inflammatory ratios, especially NLR and MLR, may be useful to detect this activation.
Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR, MLR and PLR in non-affective psychosis. Methods: Eight studies have been identified from the main electronic databases. Meta-analyses based on random-effects models have been carried out generating pooled standardised mean differences (SMDs) between non-affective psychoticpatients and healthy controls (HCs). Results: Subjects with non-affective psychosis had a significant higher NLR and MLR as compared with HC (respectively SMD = 0.715; P < 0.001; I2=57.565% and SMD = 0.417; P = 0.001; I2=65.754%), confirmed by heterogeneity-based sensitivity analysis. Subgroup analyses showed no differences in effect size across different study characteristics, including drug treatment status, diagnosis, and setting. Meta-regression showed that age influenced the relationship between non-affective psychosis and MLR. A trend of significance, not confirmed by heterogeneity-based sensitivity analysis, was observed in PLR with patients showing higher PLR than HC.Conclusions: Our meta-analysis supports the hypothesis that an inflammatory activation occurs in non-affective psychosis and inflammatory ratios, especially NLR and MLR, may be useful to detect this activation.
Authors: Eilis Hannon; Emma L Dempster; Georgina Mansell; Joe Burrage; Nick Bass; Marc M Bohlken; Aiden Corvin; Charles J Curtis; David Dempster; Marta Di Forti; Timothy G Dinan; Gary Donohoe; Fiona Gaughran; Michael Gill; Amy Gillespie; Cerisse Gunasinghe; Hilleke E Hulshoff; Christina M Hultman; Viktoria Johansson; René S Kahn; Jaakko Kaprio; Gunter Kenis; Kaarina Kowalec; James MacCabe; Colm McDonald; Andrew McQuillin; Derek W Morris; Kieran C Murphy; Colette J Mustard; Igor Nenadic; Michael C O'Donovan; Diego Quattrone; Alexander L Richards; Bart Pf Rutten; David St Clair; Sebastian Therman; Timothea Toulopoulou; Jim Van Os; John L Waddington; Patrick Sullivan; Evangelos Vassos; Gerome Breen; David Andrew Collier; Robin M Murray; Leonard S Schalkwyk; Jonathan Mill Journal: Elife Date: 2021-02-26 Impact factor: 8.140
Authors: Tyler R Prestwood; Roshanak Asgariroozbehani; Sally Wu; Sri Mahavir Agarwal; Ryan W Logan; Jacob S Ballon; Margaret K Hahn; Zachary Freyberg Journal: Behav Brain Res Date: 2021-01-14 Impact factor: 3.332
Authors: Heather E Soder; Amber M Berumen; Kira E Gomez; Charles E Green; Robert Suchting; Margaret C Wardle; Jessica Vincent; Antonio L Teixeira; Joy M Schmitz; Scott D Lane Journal: Clin Psychopharmacol Neurosci Date: 2020-02-29 Impact factor: 2.582