Literature DB >> 30805967

A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples.

Wenpeng Zhang1,2, Spencer Chiang1,2, Zishuai Li1, Qinhua Chen3, Yu Xia4, Zheng Ouyang1,2.   

Abstract

A porous polymer coating transfer enrichment method is developed for the direct mass spectrometry (MS) analysis of lipids. The enrichment is fast (ca. 1 min) and enables the profiling and quantitation of lipids in small-volume biofluid samples. Coupled with a photochemical Paternò-Büchi reaction, this method enables the fast determination of lipid structure at the C=C location level and point-of-care lipid biomarker analysis.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  analyte enrichment; biofluids; lipid isomers; mass spectrometry; polymer coatings

Year:  2019        PMID: 30805967      PMCID: PMC6541494          DOI: 10.1002/anie.201900011

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN: 1433-7851            Impact factor:   15.336


  43 in total

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Review 4.  Lipid parameters for measuring risk of cardiovascular disease.

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Journal:  J Lipid Res       Date:  2010-07-29       Impact factor: 5.922

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8.  Mass spectrometry sampling under ambient conditions with desorption electrospray ionization.

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10.  Ozone-induced dissociation: elucidation of double bond position within mass-selected lipid ions.

Authors:  Michael C Thomas; Todd W Mitchell; David G Harman; Jane M Deeley; Jessica R Nealon; Stephen J Blanksby
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Review 3.  Review of Recent Advances in Lipid Analysis of Biological Samples via Ambient Ionization Mass Spectrometry.

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4.  In-situ sampling of lipids in tissues using a porous membrane microprobe for direct mass spectrometry analysis.

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