N H Meshram1,2, D Jackson3, T Varghese1,2, C C Mitchell4, S M Wilbrand5, R J Dempsey5, B P Hermann3. 1. Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 2. Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, USA. 3. Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 4. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 5. Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Abstract
OBJECTIVE: We examine the relationship between variability in the plaque strain distribution estimated using ultrasound with multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. METHOD: Asymptomatic (n = 42) and symptomatic (n = 34) patients with significant (>60%) carotid artery stenosis were studied for plaque instability using ultrasound strain imaging and multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. Correlation and ROC analyses were performed between ultrasound strain indices and cognitive function. Strain indices and cognition scores were also compared between symptomatic and asymptomatic patients to determine whether there are significant group differences. RESULTS: Association of high-strain distributions with dysexecutive function was observed in both asymptomatic and symptomatic patients. For memory, visuospatial, and language functions, the correlations between strain and cognition were weaker for the asymptomatic compared to symptomatic group. CONCLUSIONS: Both asymptomatic and symptomatic patients demonstrate a relationship between vessel strain indices and executive function indicating that silent strokes and micro-emboli could initially contribute to a decline in executive function, whereas strokes and transient ischemic attacks may cause the further decline in other cognitive functions.
OBJECTIVE: We examine the relationship between variability in the plaque strain distribution estimated using ultrasound with multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. METHOD: Asymptomatic (n = 42) and symptomatic (n = 34) patients with significant (>60%) carotid artery stenosis were studied for plaque instability using ultrasound strain imaging and multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. Correlation and ROC analyses were performed between ultrasound strain indices and cognitive function. Strain indices and cognition scores were also compared between symptomatic and asymptomatic patients to determine whether there are significant group differences. RESULTS: Association of high-strain distributions with dysexecutive function was observed in both asymptomatic and symptomatic patients. For memory, visuospatial, and language functions, the correlations between strain and cognition were weaker for the asymptomatic compared to symptomatic group. CONCLUSIONS: Both asymptomatic and symptomatic patients demonstrate a relationship between vessel strain indices and executive function indicating that silent strokes and micro-emboli could initially contribute to a decline in executive function, whereas strokes and transient ischemic attacks may cause the further decline in other cognitive functions.
Authors: Xiao Wang; Daren C Jackson; Tomy Varghese; Carol C Mitchell; Bruce P Hermann; Mark A Kliewer; Robert J Dempsey Journal: Ultrasound Med Biol Date: 2013-10-11 Impact factor: 2.998
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Authors: Xiao Wang; Daren C Jackson; Carol C Mitchell; Tomy Varghese; Stephanie M Wilbrand; Brandon G Rocque; Bruce P Hermann; Robert J Dempsey Journal: Ultrasound Med Biol Date: 2016-01-05 Impact factor: 2.998
Authors: Vladimir Hachinski; Costantino Iadecola; Ron C Petersen; Monique M Breteler; David L Nyenhuis; Sandra E Black; William J Powers; Charles DeCarli; Jose G Merino; Raj N Kalaria; Harry V Vinters; David M Holtzman; Gary A Rosenberg; Anders Wallin; Martin Dichgans; John R Marler; Gabrielle G Leblanc Journal: Stroke Date: 2006-08-17 Impact factor: 7.914
Authors: Nirvedh H Meshram; Daren Jackson; Carol C Mitchell; Stephanie M Wilbrand; Robert J Dempsey; Bruce P Hermann; Tomy Varghese Journal: Annu Int Conf IEEE Eng Med Biol Soc Date: 2020-07