Hamidreza Yazdi1,2,3,4,5,6, Alireza Yousof Gomrokchi1,2,3,4,5,6, Ara Nazarian1,2,3,4,5,6, Aron Lechtig1,2,3,4,5,6, Philip Hanna1,2,3,4,5,6, Mohammad Ghorbanhoseini1,2,3,4,5,6. 1. Department of knee Surgery, bone and joint reconstruction research center, Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran. 2. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran. 3. Center for Advanced Orthopaedic Studies at BIDMC, Harvard Medical School, Boston, MA, USA. 4. Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA. 5. Tufts Medical Center, Boston, USA. 6. Research performed at Orthopaedic Department of firoozgar hospital, Iran University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Arthroscopic reconstruction of ACL is an effective method to restore knee stability after ACL rupture. Postoperative septic arthritis (SA) is very uncommon while the incidence of serious complications range between 0.14% and 1.8%. Some of the devastating consequences of septic arthritis can encompass hyaline cartilage damage, arthrofibrosis, and in rare cases amputation. The purpose of this study was to evaluate the effect of gentamicin irrigation solutions as a process to restrain septic arthritis following arthroscopic ACL reconstruction. METHODS: In this retrospective cohort study, 1464 patients who underwent ACL reconstruction with hamstring tendon autograft in our institution over 7 years (February 2008 to January 2015) were included. The patients were divided into two groups based on the type of intra-articular irrigation solution used during the surgery. Patients in Group 1 (Saline) received intra-articular irrigation with normal saline (0.9 % sodium chloride) solution, while those in Group 2 (Gentamycin) received intra-articular irrigation with gentamicin (80 mg/L) added to the normal saline solution. Data about postoperative infection, its course, management, and outcome were obtained from patients' records. RESULTS: Seven patients developed SA, four of whom were from SALINE group (2.2%) and three from Gentamycin group (0.23%). The incidence rate of SA after arthroscopic ACL reconstruction was significantly lower (P <0.05) when irrigated with gentamicin solution than merely with saline solution. CONCLUSION: Gentamicin irrigation solution has a preservative and protective effect against SA development following arthroscopic ACL reconstruction. We recommend evaluating this technique as a way in order to depreciate the prevalence of SA after ACL reconstruction.
BACKGROUND: Arthroscopic reconstruction of ACL is an effective method to restore knee stability after ACL rupture. Postoperative septic arthritis (SA) is very uncommon while the incidence of serious complications range between 0.14% and 1.8%. Some of the devastating consequences of septic arthritis can encompass hyaline cartilage damage, arthrofibrosis, and in rare cases amputation. The purpose of this study was to evaluate the effect of gentamicin irrigation solutions as a process to restrain septic arthritis following arthroscopic ACL reconstruction. METHODS: In this retrospective cohort study, 1464 patients who underwent ACL reconstruction with hamstring tendon autograft in our institution over 7 years (February 2008 to January 2015) were included. The patients were divided into two groups based on the type of intra-articular irrigation solution used during the surgery. Patients in Group 1 (Saline) received intra-articular irrigation with normal saline (0.9 % sodium chloride) solution, while those in Group 2 (Gentamycin) received intra-articular irrigation with gentamicin (80 mg/L) added to the normal saline solution. Data about postoperative infection, its course, management, and outcome were obtained from patients' records. RESULTS: Seven patients developed SA, four of whom were from SALINE group (2.2%) and three from Gentamycin group (0.23%). The incidence rate of SA after arthroscopic ACL reconstruction was significantly lower (P <0.05) when irrigated with gentamicin solution than merely with saline solution. CONCLUSION: Gentamicin irrigation solution has a preservative and protective effect against SA development following arthroscopic ACL reconstruction. We recommend evaluating this technique as a way in order to depreciate the prevalence of SA after ACL reconstruction.
Authors: Robert T Burks; Matthew G Friederichs; Barbara Fink; Mark G Luker; Hugh S West; Patrick E Greis Journal: Am J Sports Med Date: 2003 May-Jun Impact factor: 6.202
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Authors: I Geethan; Raju Easwaran; Santhosh Sahanand; Arumugam Sivaraman; Arun Gupta; Ashish Devgan; S Ashok; V B Bhasin; Clement Joseph; Deepak Chaudhary; Dinshaw N Pardiwala; P Gopinathan; John Thayyil John; J Maheshwari; Manabendra Nath Basumallick; Nicholas Antao; Nishith Shah; Palanivel Rajan; Parag Sancheti; Paresh Chandra Dey; Prakash Ayyadurai; Prateek Kr Gupta; K Raghuveer Reddy; Ravi Gupta; Ravi Mittal; Sachin Tapasvi; Schiller Thekekara Jos; Skand Sinha; S R Sundararajan; Vinod Kumar; Vivek Pandey; David V Rajan Journal: Indian J Orthop Date: 2021-02-01 Impact factor: 1.251