Literature DB >> 30805300

Corrigendum: Metabolic Dependencies in Pancreatic Cancer.

Ali Vaziri-Gohar1, Mahsa Zarei2,3, Jonathan R Brody4, Jordan M Winter1,5.   

Abstract

[This corrects the article DOI: 10.3389/fonc.2018.00617.].

Entities:  

Keywords:  metabolic dependencies; metabolism; pancreatic cancer; redox homeostasis; targeting metabolism

Year:  2019        PMID: 30805300      PMCID: PMC6371022          DOI: 10.3389/fonc.2018.00672

Source DB:  PubMed          Journal:  Front Oncol        ISSN: 2234-943X            Impact factor:   6.244


In the original article, all references for in Tables 1, 2 were incorrectly listed. The corrected references for both Table 1 and Table 2 have been corrected and provided below.
Table 1

Metabolic dependencies in PDA.

EventMediated byReferences
MITOCHONDRIAL METABOLISM
Increased oxidative phosphorylationDown regulation of Drp1(61)
HuR(50)
Increased biogenesisHuRUnpublished
NUTRIENT ACQUISITION
AutophagyOncogenic KRAS(74)
NAD+ salvage pathwaymiR-206(78, 79)
MacropinocytosisOncogenic KRAS(35)
Increased alanine uptakeOncogenic KRAS(85)
REDOX HOMEOSTASIS
Upregulation of ME1Oncogenic KRAS(57)
Upregulation of NRF2Oncogenic KRAS(97)
Upregulation of IDH1HuR(50)
Table 2

Clinical trials targeting key steps of PDA metabolism.

TargetAgentPhase and statusNCT No.References
MITOCHONDRIAL OXPHOS
ETCMetformin + gemcitabine + ertotinibII; CompletedNCT01210911(63)
Metformin + paclitaxelII; CompletedNCT01971034(103)
Metformin + gemcitabine/nab-paclitaxelI; RecruitingNCT02336087
Metformin + mFOLFIRINOXII; ActiveNCT01666730
Metformin + rapamycinIb; ActiveNCT02048384
Metformin + radiosurgeryI; ActiveNCT02153450
TCA cycleCPI-613I; CompletedNCT01839981
CPI-613 + mFOLFIRINOXI; ActiveNCT01835041(67)
CPI-613 + gemcitabine/nab-paclitaxelI; ActiveNCT03435289
NUTRIENT ACQUISITION
AutophagyHCQII; CompletedNCT01273805(104)
HCQ + gemcitabineI/II; ActiveNCT01128296
HCQ + gemcitabine + abraxaneI/II; ActiveNCT01506973
CQ + gemcitabineI; CompletedNCT01777477(105, 106)
REDOX HOMEOSTASIS
GlutaminaseCB-839I; ActiveNCT02071862

HCQ, hydroxychloroquine; CQ, chloroquine; mFOLFIRINOX, modified FOLFIRINOX.

Metabolic dependencies in PDA. Clinical trials targeting key steps of PDA metabolism. HCQ, hydroxychloroquine; CQ, chloroquine; mFOLFIRINOX, modified FOLFIRINOX. In the original article, references in Table 2 were not provided in the reference list. The references have now been inserted. The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.
  15 in total

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