Konstantinos Sfakianoudis1, Mara Simopoulou2, Nikolaos Nitsos3, Leandros Lazaros4, Anna Rapani5, Agni Pantou1, Michael Koutsilieris5, Yorgos Nikas6, Konstantinos Pantos1. 1. Reproductive Medicine Unit, Genesis Athens Clinic, Athens, Greece. 2. Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece marasimopoulou@hotmail.com. 3. Genesis Athens Clinic, Microbiology-Biochemical Department, Athens, Greece. 4. Genesis Genoma Lab, Molecular Genetics, Athens, Greece. 5. Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. 6. Athens Innovative Microscopy, Athens, Greece.
Abstract
BACKGROUND/AIM: Patients diagnosed with chronic endometritis (CE) may fail to respond to standard antibiotic treatment. The driver behind the approach reported here was the imperative need for alternative therapeutic solutions. CASE REPORT: This case report presents a woman with CE and premature ovarian insufficiency having experienced repeated implantation failures following donated embryo transfers. The patient was diagnosed with CE through hysteroscopy, microbiological analysis and scanning electron microscopy. Following the suggested antibiotic treatment, she underwent a new embryo transfer, but with subsequent pregnancy loss. Following a second antibiotic scheme, all diagnostic procedures certified the persistence of CE. The patient underwent autologous, intrauterine platelet-rich plasma treatment and a subsequent embryo transfer. The diagnostic procedures indicated no signs of CE, while the embryo transfer resulted in a twin pregnancy and birth. CONCLUSION: Platelet-rich plasma may be employed as a first-line CE treatment, especially for patients who fail to respond to conventional antibiotic schemes. Copyright
BACKGROUND/AIM: Patients diagnosed with chronic endometritis (CE) may fail to respond to standard antibiotic treatment. The driver behind the approach reported here was the imperative need for alternative therapeutic solutions. CASE REPORT: This case report presents a woman with CE and premature ovarian insufficiency having experienced repeated implantation failures following donated embryo transfers. The patient was diagnosed with CE through hysteroscopy, microbiological analysis and scanning electron microscopy. Following the suggested antibiotic treatment, she underwent a new embryo transfer, but with subsequent pregnancy loss. Following a second antibiotic scheme, all diagnostic procedures certified the persistence of CE. The patient underwent autologous, intrauterine platelet-rich plasma treatment and a subsequent embryo transfer. The diagnostic procedures indicated no signs of CE, while the embryo transfer resulted in a twin pregnancy and birth. CONCLUSION: Platelet-rich plasma may be employed as a first-line CE treatment, especially for patients who fail to respond to conventional antibiotic schemes. Copyright
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