Nicola Sardaro1, Fedora Della Vella2, Maria Angela Incalza3, Dario DI Stasio4, Alberta Lucchese4, Maria Contaldo4, Claudia Laudadio2, Massimo Petruzzi5. 1. Section of Biochemistry, Department of Basic Medical Science, Neuroscience and Organs of Sense, School of Medicine, Aldo Moro University of Bari, Bari, Italy. 2. Section of Dentistry, Interdisciplinary Department of Medicine, School of Medicine, Aldo Moro University of Bari, Bari, Italy. 3. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, Aldo Moro University of Bari, Bari, Italy. 4. Multidisciplinary Department of Medical, Surgical and Dental Specialties, Luigi Vanvitelli University of Campania, Naples, Italy. 5. Section of Dentistry, Interdisciplinary Department of Medicine, School of Medicine, Aldo Moro University of Bari, Bari, Italy massimo.petruzzi@uniba.it.
Abstract
BACKGROUND: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. MATERIALS AND METHODS: Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. RESULTS: This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. CONCLUSION: Although variability in findings between individual studies exists, it justifies the conclusion that oxidative stress is a significant process in the oral mucosal diseases pathogenesis. Copyright
BACKGROUND:Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. MATERIALS AND METHODS: Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. RESULTS: This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. CONCLUSION: Although variability in findings between individual studies exists, it justifies the conclusion that oxidative stress is a significant process in the oral mucosal diseases pathogenesis. Copyright
Authors: Maaret Eskelinen; Iina Saimanen; Riika Koskela; Anu Holopainen; Tuomas Selander; Matti Eskelinen Journal: In Vivo Date: 2022 Mar-Apr Impact factor: 2.155
Authors: Flávia Póvoa da Costa; Bruna Puty; Lygia S Nogueira; Geovanni Pereira Mitre; Sávio Monteiro Dos Santos; Bruno José Brito Teixeira; Maria Sueli da Silva Kataoka; Manoela Domingues Martins; Carlos Augusto Galvão Barboza; Marta Chagas Monteiro; Hervé Rogez; Edivaldo Herculano Corrêa de Oliveira; Rafael Rodrigues Lima Journal: Antioxidants (Basel) Date: 2019-12-23