Literature DB >> 30803966

A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance.

Jessie E Wozniak1,2,3,4, Victor I Band1,2,3,4, Andrew B Conley5, Lavanya Rishishwar5, Eileen M Burd3,4, Sarah W Satola3,4, Dwight J Hardy6, Rebecca Tsay6, Monica M Farley3,4,7, Jesse T Jacob3,4, Ghinwa Dumyati6, I King Jordan5,8, David S Weiss9,3,4,7.   

Abstract

The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR) K. pneumoniae isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced K. pneumoniae surveillance.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  KPC; Klebsiella; colistin; heteroresistance; hypermucoviscous

Year:  2019        PMID： 30803966      PMCID： PMC6496084          DOI： 10.1128/AAC.00107-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

Authors:  Marcus Ho Yin Wong; Hoi-Ping Shum; Jonathan Hon Kwan Chen; Man-Yee Man; Alan Wu; Edward Wai-Chi Chan; Kwok-Yung Yuen; Sheng Chen
Journal:  Lancet Infect Dis       Date:  2017-11-01       Impact factor: 25.071

2.  Septic arthritis subsequent to urosepsis caused by hypermucoviscous Klebsiella pneumoniae.

Authors:  Kei Suzuki; Akiko Nakamura; Tomoyuki Enokiya; Yoshiaki Iwashita; Eri Tomatsu; Yuichi Muraki; Toshihiro Kaneko; Masahiro Okuda; Naoyuki Katayama; Hiroshi Imai
Journal:  Intern Med       Date:  2013-07-15       Impact factor: 1.271

Review 3.  Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance.

Authors:  Johann D D Pitout; Patrice Nordmann; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

4.  A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study.

Authors:  Danxia Gu; Ning Dong; Zhiwei Zheng; Di Lin; Man Huang; Lihua Wang; Edward Wai-Chi Chan; Lingbin Shu; Jiang Yu; Rong Zhang; Sheng Chen
Journal:  Lancet Infect Dis       Date:  2017-08-29       Impact factor: 25.071

5.  Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China.

Authors:  Wei Li; Guizhen Sun; Yanhua Yu; Ning Li; Ming Chen; Ronghua Jin; Yanmei Jiao; Hao Wu
Journal:  Clin Infect Dis       Date:  2013-10-07       Impact factor: 9.079

6.  Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes.

Authors:  Wen-Liang Yu; Wen-Chien Ko; Kuo-Chen Cheng; Ching-Chien Lee; Chien-Cherng Lai; Yin-Ching Chuang
Journal:  Diagn Microbiol Infect Dis       Date:  2008-05-16       Impact factor: 2.803

7.  Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007-2013).

Authors:  M Cubero; I Grau; F Tubau; R Pallarés; M A Dominguez; J Liñares; C Ardanuy
Journal:  Clin Microbiol Infect       Date:  2015-10-08       Impact factor: 8.067

8.  Whole genome sequence of Klebsiella pneumoniae U25, a hypermucoviscous, multidrug resistant, biofilm producing isolate from India.

Authors:  Zumaana Rafiq; Nithin Sam; Rama Vaidyanathan
Journal:  Mem Inst Oswaldo Cruz       Date:  2016-02       Impact factor: 2.743

Review 9.  Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed.

Authors:  Alyssa S Shon; Rajinder P S Bajwa; Thomas A Russo
Journal:  Virulence       Date:  2013-01-09       Impact factor: 5.882

10.  Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections.

Authors:  Fiorella Krapp; Andrew R Morris; Egon A Ozer; Alan R Hauser
Journal:  Sci Rep       Date:  2017-10-19       Impact factor: 4.379
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  10 in total

1.  Molecular Epidemiology of Hypervirulent K. pneumoniae and Problems of Health-Care Associated Infections.

Authors:  A V Tutelyan; D S Shlykova; Sh L Voskanyan; A M Gaponov; V M Pisarev
Journal:  Bull Exp Biol Med       Date:  2022-03-30       Impact factor: 0.737

Review 2.  Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives.

Authors:  J E Choby; J Howard-Anderson; D S Weiss
Journal:  J Intern Med       Date:  2019-11-21       Impact factor: 8.989

3.  Colistin Heteroresistance in Klebsiella Pneumoniae Isolates and Diverse Mutations of PmrAB and PhoPQ in Resistant Subpopulations.

Authors:  Hae Suk Cheong; So Yeon Kim; Yu Mi Wi; Kyong Ran Peck; Kwan Soo Ko
Journal:  J Clin Med       Date:  2019-09-11       Impact factor: 4.241

4.  The Galleria mellonella Infection Model Does Not Accurately Differentiate between Hypervirulent and Classical Klebsiella pneumoniae.

Authors:  Thomas A Russo; Ulrike MacDonald
Journal:  mSphere       Date:  2020-01-08       Impact factor: 4.389

5.  Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.

Authors:  Homer Pantua; Elizabeth Skippington; Marie-Gabrielle Braun; Cameron L Noland; Jingyu Diao; Yutian Peng; Susan L Gloor; Donghong Yan; Jing Kang; Anand Kumar Katakam; Janina Reeder; Georgette M Castanedo; Keira Garland; Laszlo Komuves; Meredith Sagolla; Cary D Austin; Jeremy Murray; Yiming Xu; Zora Modrusan; Min Xu; Emily J Hanan; Sharookh B Kapadia
Journal:  mBio       Date:  2020-09-08       Impact factor: 7.867

6.  Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria.

Authors:  Jun Li; Mengli Tang; Fengjun Xia; Changhang Min; Yongmei Hu; Haichen Wang; Mingxiang Zou
Journal:  BMC Microbiol       Date:  2022-02-07       Impact factor: 3.605

7.  Nosocomial dissemination of hypervirulent Klebsiella pneumoniae with high-risk clones among children in Shanghai.

Authors:  Qingqing Du; Fen Pan; Chun Wang; Fangyuan Yu; Yingying Shi; Wenxin Liu; Zhi Li; Ping He; Dingding Han; Hong Zhang
Journal:  Front Cell Infect Microbiol       Date:  2022-08-29       Impact factor: 6.073

Review 8.  Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings.

Authors:  Mohammad Abavisani; Mansoor Kodori; Fariba Akrami; Ali Radfar; Ali Hashemi
Journal:  Can J Infect Dis Med Microbiol       Date:  2022-09-19       Impact factor: 2.585

9.  Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.

Authors:  Julian R Braxton; Carlos A Rodriguez-Osorio; Anna P Zagieboylo; Christoph M Ernst; Li Li; Alejandro Pironti; Abigail L Manson; Anil V Nair; Maura Benson; Kaelyn Cummins; Anne E Clatworthy; Ashlee M Earl; Lisa A Cosimi; Deborah T Hung
Journal:  Nat Med       Date:  2020-04-13       Impact factor: 87.241

10.  In vitro Activity of Apramycin Against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

Authors:  Mingju Hao; Xiaohong Shi; Jingnan Lv; Siqiang Niu; Shiqing Cheng; Hong Du; Fangyou Yu; Yi-Wei Tang; Barry N Kreiswirth; Haifang Zhang; Liang Chen
Journal:  Front Microbiol       Date:  2020-03-13       Impact factor: 5.640
  10 in total

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