BACKGROUND: Silver diamine fluoride (SDF) is used topically to prevent or arrest caries. The authors' aim was to characterize the kinetics of silver and fluoride after topical application of SDF. METHODS: Sixteen adults participated in a pharmacokinetics study after the application of 38% SDF to 5 teeth (approximately 50 microliters, estimated 4-11 milligrams per participant). Serum and urine samples were collected over 24 hours after application and were analyzed for silver and fluoride. RESULTS: Silver serum peak was 0.67 (standard deviation [SD], 0.49) nanograms per milliliter; median time to peak was 3 hours. The estimated elimination half-life of silver was 46 (SD, 26) hours. No silver was recovered in urine. Baseline fluoride serum levels ranged from less than 10 through 50 ng/mL (< 0.01-0.05 parts per million) and fluctuated around baseline after SDF. The 24-hour urinary fluoride was 1.29 (SD, 0.81) mg. CONCLUSIONS: SDF was well tolerated in this study, and no adverse events related to SDF were reported. PRACTICAL IMPLICATIONS: This clinical study confirmed that topical application of 38% SDF, in growing use in the United States, is safe and well tolerated in healthy adults.
BACKGROUND:Silver diamine fluoride (SDF) is used topically to prevent or arrest caries. The authors' aim was to characterize the kinetics of silver and fluoride after topical application of SDF. METHODS: Sixteen adults participated in a pharmacokinetics study after the application of 38% SDF to 5 teeth (approximately 50 microliters, estimated 4-11 milligrams per participant). Serum and urine samples were collected over 24 hours after application and were analyzed for silver and fluoride. RESULTS:Silver serum peak was 0.67 (standard deviation [SD], 0.49) nanograms per milliliter; median time to peak was 3 hours. The estimated elimination half-life of silver was 46 (SD, 26) hours. No silver was recovered in urine. Baseline fluoride serum levels ranged from less than 10 through 50 ng/mL (< 0.01-0.05 parts per million) and fluctuated around baseline after SDF. The 24-hour urinary fluoride was 1.29 (SD, 0.81) mg. CONCLUSIONS:SDF was well tolerated in this study, and no adverse events related to SDF were reported. PRACTICAL IMPLICATIONS: This clinical study confirmed that topical application of 38% SDF, in growing use in the United States, is safe and well tolerated in healthy adults.
Authors: E A Martínez-Mier; J A Cury; J R Heilman; B P Katz; S M Levy; Y Li; A Maguire; J Margineda; D O'Mullane; P Phantumvanit; A E Soto-Rojas; G K Stookey; A Villa; J S Wefel; H Whelton; G M Whitford; D T Zero; W Zhang; V Zohouri Journal: Caries Res Date: 2010-12-11 Impact factor: 4.056
Authors: Salmaan Kanji; Meghan Hayes; Adam Ling; Larissa Shamseer; Clarence Chant; David J Edwards; Scott Edwards; Mary H H Ensom; David R Foster; Brian Hardy; Tyree H Kiser; Charles la Porte; Jason A Roberts; Rob Shulman; Scott Walker; Sheryl Zelenitsky; David Moher Journal: Clin Pharmacokinet Date: 2015-07 Impact factor: 6.447