Katarzyna Kotfis1, Xavier Wittebole2, Ulrich Jaschinski3, Jordi Solé-Violán4, Rahul Kashyap5, Marc Leone6, Rahul Nanchal7, Luis E Fontes8, Yasser Sakr9, Jean-Louis Vincent10. 1. Dept of Anaesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University, Szczecin, Poland. 2. Dept of Critical Care, Cliniques Universitaires St Luc, UCL, Brussels, Belgium. 3. Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Augsburg, Germany. 4. Dept of Intensive Care, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. 5. Dept of Anesthesia & Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. 6. Service d'Anesthésie et de Réanimation, Aix Marseille Université, APHM, Hôpital Nord, Marseille, France. 7. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. 8. Department of Intensive Care and Evidence-Based Medicine, Hospital Alcides Carneiro, Petrópolis Medical School, Petrópolis, Brazil. 9. Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany. 10. Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: jlvincent@intensive.org.
Abstract
PURPOSE: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. METHODS: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure. RESULTS: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying. CONCLUSIONS: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.
PURPOSE: To investigate age-related differences in outcomes of critically illpatients with sepsis around the world. METHODS: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure. RESULTS: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying. CONCLUSIONS: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.
Authors: Jeannie P Cimiotti; Edmund R Becker; Yin Li; Douglas M Sloane; Scott K Fridkin; Anna Beth West; Linda H Aiken Journal: JAMA Health Forum Date: 2022-05-27
Authors: Amal Abouda; Z Hajjej; A Mansart; W Kaabechi; D Elhaj Mahmoud; O Lamine; E Ghazouani; M Ferjani; I Labbene Journal: J Immunol Res Date: 2022-05-31 Impact factor: 4.493