| Literature DB >> 30802685 |
Ling Huang1, Eugenia Kakadiaris1, Tereza Vaneckova2, Kai Huang1, Marketa Vaculovicova3, Gang Han4.
Abstract
Organic triplet-triplet annihilation upconversion (TTA-UC) nanoparticles have emerged as exciting therapeutic agents and imaging probes in recent years due to their unique chemical and optical properties such as outstanding biocompatibility and low power excitation density. In this review, we focus on the latest breakthroughs in such new version of upconversion nanoparticle, including their design, preparation, and applications. First, we will discuss the key principles and design concept of these organic-based photon upconversion in regard to the methods of selection of the related triplet TTA dye pairs (photosensitizer and emitter). Then, we will discuss the recent approaches s to construct TTA-UCNPs including silica TTA-UCNPs, lipid-coated TTA-UCNPs, polymer encapsulated TTA-UCNPs, nano-droplet TTA-UCNPs and metal-organic frameworks (MOFs) constructed TTA-UCNPs. In addition, the applications of TTA-UCNPs will be discussed. Finally, we will discuss the challenges posed by current TTA-UCNP development.Entities:
Keywords: And cancer therapy; Bioimaging; Nanoparticles; Photo-targeting; Triplet-triplet annihilation upconversion
Mesh：
Substances：
Year: 2019 PMID： 30802685 PMCID： PMC6467534 DOI： 10.1016/j.biomaterials.2019.02.008
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479