A DIRECT SEMIPARAMETRIC RECEIVER OPERATING CHARACTERISTIC CURVE REGRESSION WITH UNKNOWN LINK AND BASELINE FUNCTIONS.

In this article, we study a direct receiver operating characteristic (ROC) curve regression model with completely unknown link and baseline functions. A semiparametric procedure is proposed to estimate both the parametric and non-parametric components of the model. The resulting parameter estimates and ROC curve estimates are shown to be consistent and asymptotically normal with a n -1/2 convergence rate. With arbitrary link and baseline functions, our model is more robust than existing direct ROC regression models that require either complete or partially complete specification of the link and baseline functions. Moreover, the robustness of our new method is gained at little cost to efficiency, as evidenced by the parametric convergence rate of our estimators and by the simulation study. An illustrative example is given using a hearing test data set.