Literature DB >> 30799186

ACMSD: A Novel Target for Modulating NAD+ Homeostasis.

Jun Yoshino1.   

Abstract

NAD+ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359-1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD+ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD+ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD+ deficiency.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ACMSD; NAD(+); metabolism; niacin; tryptophan

Year:  2019        PMID： 30799186      PMCID： PMC6858840          DOI： 10.1016/j.tem.2019.02.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  10 in total

1.  The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.

Authors:  Jose Felix Martí-Massó; Alberto Bergareche; Vladimir Makarov; Javier Ruiz-Martinez; Ana Gorostidi; Adolfo López de Munain; Juan Jose Poza; Pasquale Striano; Joseph D Buxbaum; Coro Paisán-Ruiz
Journal:  J Mol Med (Berl)       Date:  2013-08-20       Impact factor: 4.599

2.  Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

Authors:  Akiko Satoh; Cynthia S Brace; Nick Rensing; Paul Cliften; David F Wozniak; Erik D Herzog; Kelvin A Yamada; Shin-Ichiro Imai
Journal:  Cell Metab       Date:  2013-09-03       Impact factor: 27.287

Review 3.  Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Authors:  Luis Rajman; Karolina Chwalek; David A Sinclair
Journal:  Cell Metab       Date:  2018-03-06       Impact factor: 27.287

Review 4.  Niacin-tryptophan relationships for evaluating niacin equivalents.

Authors:  M K Horwitt; A E Harper; L M Henderson
Journal:  Am J Clin Nutr       Date:  1981-03       Impact factor: 7.045

5.  Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

Authors:  R Schwarcz; W O Whetsell; R M Mangano
Journal:  Science       Date:  1983-01-21       Impact factor: 47.728

Review 6.  NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR.

Authors:  Jun Yoshino; Joseph A Baur; Shin-Ichiro Imai
Journal:  Cell Metab       Date:  2017-12-14       Impact factor: 27.287

7.  Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis.

Authors:  Laura Palzer; Jessica J Bader; Frances Angel; Megan Witzel; Sydney Blaser; Alexis McNeil; Miles K Wandersee; N Adrian Leu; Christopher J Lengner; Clara E Cho; Kevin D Welch; James B Kirkland; Ralph G Meyer; Mirella L Meyer-Ficca
Journal:  Cell Rep       Date:  2018-10-30       Impact factor: 9.423

Review 8.  The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.

Authors:  Eduardo N Chini; Claudia C S Chini; Jair Machado Espindola Netto; Guilherme C de Oliveira; Wim van Schooten
Journal:  Trends Pharmacol Sci       Date:  2018-02-23       Impact factor: 14.819

9.  De novo NAD+ biosynthetic impairment in acute kidney injury in humans.

Authors:  Ali Poyan Mehr; Mei T Tran; Kenneth M Ralto; David E Leaf; Vaughan Washco; Joseph Messmer; Adam Lerner; Ajay Kher; Steven H Kim; Charbel C Khoury; Shoshana J Herzig; Mary E Trovato; Noemie Simon-Tillaux; Matthew R Lynch; Ravi I Thadhani; Clary B Clish; Kamal R Khabbaz; Eugene P Rhee; Sushrut S Waikar; Anders H Berg; Samir M Parikh
Journal:  Nat Med       Date:  2018-08-20       Impact factor: 53.440

10.  De novo NAD+ synthesis enhances mitochondrial function and improves health.

Authors:  Elena Katsyuba; Adrienne Mottis; Marika Zietak; Francesca De Franco; Vera van der Velpen; Karim Gariani; Dongryeol Ryu; Lucia Cialabrini; Olli Matilainen; Paride Liscio; Nicola Giacchè; Nadine Stokar-Regenscheit; David Legouis; Sophie de Seigneux; Julijana Ivanisevic; Nadia Raffaelli; Kristina Schoonjans; Roberto Pellicciari; Johan Auwerx
Journal:  Nature       Date:  2018-10-24       Impact factor: 49.962
  10 in total
  6 in total

1.  Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity.

Authors:  Yu Yang; Ian Davis; Tsutomu Matsui; Ivan Rubalcava; Aimin Liu
Journal:  J Biol Chem       Date:  2019-06-12       Impact factor: 5.157

2.  Identification of Genetic Variations in the NAD-Related Pathways for Patients with Major Depressive Disorder: A Case-Control Study in Taiwan.

Authors:  Daniel Tzu-Li Chen; Szu-Wei Cheng; Tiffany Chen; Jane Pei-Chen Chang; Bing-Fang Hwang; Hen-Hong Chang; Eric Y Chuang; Che-Hong Chen; Kuan-Pin Su
Journal:  J Clin Med       Date:  2022-06-23       Impact factor: 4.964

Review 3.  COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Authors:  Renata Novak Kujundžić
Journal:  Int J Mol Sci       Date:  2022-04-13       Impact factor: 6.208

Review 4.  NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential.

Authors:  Na Xie; Lu Zhang; Wei Gao; Canhua Huang; Peter Ernst Huber; Xiaobo Zhou; Changlong Li; Guobo Shen; Bingwen Zou
Journal:  Signal Transduct Target Ther       Date:  2020-10-07

Review 5.  Nicotinamide adenine dinucleotide and the sirtuins caution: Pro-cancer functions.

Authors:  Raymond D Palmer; Mauro Vaccarezza
Journal:  Aging Med (Milton)       Date:  2021-11-30

6.  Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025.

Authors:  Michele Cianci; Nicola Giacchè; Lucia Cialabrini; Andrea Carotti; Paride Liscio; Emiliano Rosatelli; Francesca De Franco; Massimiliano Gasparrini; Janet Robertson; Adolfo Amici; Nadia Raffaelli; Roberto Pellicciari
Journal:  Front Mol Biosci       Date:  2022-04-07
  6 in total

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