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Literature DB >> 3079918

Human T-cell gamma chain genes: organization, diversity, and rearrangement.

T Quertermous, C Murre, D Dialynas, A D Duby, J L Strominger, T A Waldman, J G Seidman.

Abstract

The human T-cell gamma chain genes have been characterized in an attempt to better understand their role in immune response. These immunoglobulin-like genes are encoded in the genome in variable, joining, and constant segments. The human gamma genes include at least six variable region genes, two joining segments, and two constant-region genes in germline DNA. Variable and joining segments recombine during the development of T cells to form rearranged genes. The diversity of human gamma genes produced by this recombinational mechanism is greater than that produced by the murine genome but is more limited than that of other immunoglobulin-like genes.

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Year: 1986 PMID： 3079918 DOI： 10.1126/science.3079918

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

32 in total

1. Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia. V gamma gene usage differs in mature and immature T cells.

Authors: J Hara; S H Benedict; K Yumura; K Ha-Kawa; E W Gelfand
Journal: J Clin Invest Date: 1989-04 Impact factor: 14.808

2. Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia.

Authors: A C Aisenberg; B M Wilkes; J O Jacobson
Journal: J Clin Invest Date: 1987-10 Impact factor: 14.808

3. Comparative investigations of T cell receptor gamma gene rearrangements in frozen and formalin-fixed paraffin wax-embedded tissues by capillary electrophoresis.

Authors: M Christensen; A D Funder; K Bendix; F B Soerensen
Journal: J Clin Pathol Date: 2006-02-06 Impact factor: 3.411

9. Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.

Authors: A D Duby; J G Seidman
Journal: Proc Natl Acad Sci U S A Date: 1986-07 Impact factor: 11.205

Review 10. Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic applications and their limits.

Authors: H Griesser
Journal: Virchows Arch Date: 1995 Impact factor: 4.064

Human T-cell gamma chain genes: organization, diversity, and rearrangement.

1. Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia. V gamma gene usage differs in mature and immature T cells.

2. Rearrangement of the genes for the beta and gamma chains of the T cell receptor is rarely observed in adult B cell lymphoma and chronic lymphocytic leukemia.

3. Comparative investigations of T cell receptor gamma gene rearrangements in frozen and formalin-fixed paraffin wax-embedded tissues by capillary electrophoresis.

4. Acute leukemia expressing the gamma gene product of the putative second T cell receptor.

5. Diversity in T-cell receptor gamma gene usage in intestinal epithelium.

6. Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

Review 7. Surface proteins and glycoproteins of human leucocytes.

8. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.

9. Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.

Review 10. Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic applications and their limits.