Michelle Lycke1,2, Tessa Lefebvre1,2, Lies Pottel1, Hans Pottel3, Lore Ketelaars4, Karin Stellamans5, Koen Van Eygen1,6, Philippe Vergauwe7, Patrick Werbrouck8, Lieselot Cool1, Tom Boterberg2, Nick Liefhooghe5, Patricia Schofield9, Philip R Debruyne1,9. 1. a Department of Medical Oncology , Cancer Centre, General Hospital Groeninge , Kortrijk , Belgium. 2. b Department of Radiation Oncology and Experimental Cancer Research , Ghent University , Ghent , Belgium. 3. c Department of Public Health and Primary Care @ Kulak , Catholic University Leuven Kulak , Kortrijk , Belgium. 4. d Department of Neuropsychology , General Hospital Groeninge , Kortrijk , Belgium. 5. e Department of Radiotherapy , Cancer Centre, General Hospital Groeninge , Kortrijk , Belgium. 6. f Department of Haematology , Cancer Centre, General Hospital Groeninge , Kortrijk , Belgium. 7. g Department of Gastro-Enterology , General Hospital Groeninge , Kortrijk , Belgium. 8. h Department of Urology , General Hospital Groeninge , Kortrijk , Belgium. 9. i Faculty of Health, Social Care and Education , Anglia Ruskin University , Chelmsford , UK.
Abstract
OBJECTIVES: Cognitive complaints, of objective or subjective nature, may negatively impact cancer patients' quality of life (QoL). Further, the early detection of cognitive alterations may lead to an improved QoL. However, the content of such screening is yet unclear. This paper presents long-term QoL data of cancer patients treated with curative intent and its relation with objective and subjective cognitive complaints, and patient-reported outcome measures (PROMs). METHODS: QoL data, measured by the EORTC QLQ C-30, were obtained at baseline, 6 (T1), 12 (T2), and 24 months (T3) after treatment start, and compared between patients with and without objective and subjective cognitive complaints. The predictive value of PROMs was also examined. RESULTS: QoL data at baseline was collected in 125 patients. Response rates at T1, T2, and T3 were 84.7%, 81.5%, and 83.1%, respectively. Eighty-nine patients returned their QoL questionnaires at all times. Baseline subjective cognitive complaints had a stronger association with worse scores on patients' overall QoL and QoL subscale scores than objective cognitive complaints. An exploratory analysis into the value of PROMs in predicting long-term QoL at T3 revealed a significant effect for the Hospital Anxiety and Depression Scale-Depression and FACIT Fatigue scale. CONCLUSIONS: Self-perceived cognitive alterations are negatively associated with patients' overall QoL. As these troubles may already be present at baseline, oncology nurses should screen for the early signs of subjective cognitive complaints by use of PROMs, in order to refer the patient to proper intervention programs which may lead to an improved long-term QoL and faster reintegration into society.
OBJECTIVES: Cognitive complaints, of objective or subjective nature, may negatively impact cancerpatients' quality of life (QoL). Further, the early detection of cognitive alterations may lead to an improved QoL. However, the content of such screening is yet unclear. This paper presents long-term QoL data of cancerpatients treated with curative intent and its relation with objective and subjective cognitive complaints, and patient-reported outcome measures (PROMs). METHODS: QoL data, measured by the EORTC QLQ C-30, were obtained at baseline, 6 (T1), 12 (T2), and 24 months (T3) after treatment start, and compared between patients with and without objective and subjective cognitive complaints. The predictive value of PROMs was also examined. RESULTS: QoL data at baseline was collected in 125 patients. Response rates at T1, T2, and T3 were 84.7%, 81.5%, and 83.1%, respectively. Eighty-nine patients returned their QoL questionnaires at all times. Baseline subjective cognitive complaints had a stronger association with worse scores on patients' overall QoL and QoL subscale scores than objective cognitive complaints. An exploratory analysis into the value of PROMs in predicting long-term QoL at T3 revealed a significant effect for the Hospital Anxiety and Depression Scale-Depression and FACIT Fatigue scale. CONCLUSIONS: Self-perceived cognitive alterations are negatively associated with patients' overall QoL. As these troubles may already be present at baseline, oncology nurses should screen for the early signs of subjective cognitive complaints by use of PROMs, in order to refer the patient to proper intervention programs which may lead to an improved long-term QoL and faster reintegration into society.
Entities:
Keywords:
anxiety/depression; behavioral health; quality of life; quantitative research methods; survivorship
Authors: Mackenzie E Fowler; Donna Murdaugh; Christian Harmon; Mustafa Al-Obaidi; Noha Sharafeldin; Smita Bhatia; Smith Giri; Grant R Williams Journal: J Cancer Surviv Date: 2022-09-17 Impact factor: 4.062
Authors: Ellen M P van Loon; Willemijn Ernens; Majanka H Heijenbrok-Kal; Herwin L D Horemans; Gerard M Ribbers; Martin J van den Bent Journal: J Rehabil Med Date: 2021-05-28 Impact factor: 2.912
Authors: Jorine A Vermaire; Cornelis P J Raaijmakers; Irma M Verdonck-de Leeuw; Femke Jansen; C René Leemans; Chris H J Terhaard; Caroline M Speksnijder Journal: Support Care Cancer Date: 2021-06-25 Impact factor: 3.603