Literature DB >> 3079852

Chelation in metal intoxication XVIII: Combined effects of thiamine and calcium disodium versenate on lead toxicity.

S J Flora, S Singh, S K Tandon.   

Abstract

Calcium disodium ethylenediaminetetraacetate (Ca-Na2EDTA; Versenate) was more effective than thiamine (vitamin B1) in enhancing the urinary excretion of lead, reducing tissue lead and restoring lead induced biochemical alterations in rats. However, the combination of CaNa2EDTA and vitamin B1 enhanced the beneficial effect of CaNa2EDTA in lead intoxication and was particularly effective in reducing the brain concentration of lead.

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Year:  1986        PMID: 3079852     DOI: 10.1016/0024-3205(86)90276-6

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  6 in total

1.  Therapeutic efficacy of dimercaptosuccinic acid and thiamine/ascorbic acid on lead intoxication in rats.

Authors:  S K Tandon; S J Flora
Journal:  Bull Environ Contam Toxicol       Date:  1989-11       Impact factor: 2.151

2.  Chelation in metal intoxication XXI: Chelation in lead intoxication during vitamin B complex deficiency.

Authors:  S K Tandon; S J Flora; S Singh
Journal:  Bull Environ Contam Toxicol       Date:  1986-09       Impact factor: 2.151

3.  Influence of dietary supplementation with thiamine on lead intoxication in rats.

Authors:  S J Flora; R P Sharma
Journal:  Biol Trace Elem Res       Date:  1986-08       Impact factor: 3.738

4.  Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication.

Authors:  M Dhawan; D N Kachru; S K Tandon
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

5.  The effects of thiamin on lead metabolism: organ distribution of lead 203.

Authors:  J S Kim; D L Hamilton; B R Blakley; C G Rousseaux
Journal:  Can J Vet Res       Date:  1992-07       Impact factor: 1.310

Review 6.  Chelation in metal intoxication.

Authors:  Swaran J S Flora; Vidhu Pachauri
Journal:  Int J Environ Res Public Health       Date:  2010-06-28       Impact factor: 3.390

  6 in total

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