Burt Yaszay1, Pawel P Jankowski2, Tracey P Bastrom3, Baron Lonner4, Randal Betz5, Suken Shah6, Jahangir Asghar7, Firoz Miyanji8, Amer Samdani9, Peter O Newton3. 1. Rady Children's Hospital, 3020 Children's Way, MC5062, San Diego, CA, 92123, USA. byaszay.rady@gmail.com. 2. New York University, New York, NY, USA. 3. Rady Children's Hospital, 3020 Children's Way, MC5062, San Diego, CA, 92123, USA. 4. Mount Sinai Hospital, New York, NY, USA. 5. The Institute for Spine and Scoliosis, Lawrenceville, NJ, USA. 6. Alfred I. duPont Hospital for Children, Wilmington, DE, USA. 7. Nicklaus Children's Hospital, Miami, FL, USA. 8. British Columbia Children's Hospital, Vancouver, BC, Canada. 9. Shriners Hospitals for Children, Philadelphia, PA, USA.
Abstract
PURPOSE: To evaluate changes in pulmonary function tests (PFT) at 5 years post-operatively in patients with adolescent idiopathic scoliosis (AIS) and to determine whether these changes are progressive or static after 2 years. METHODS: AIS surgical patients with pre-operative and 5 year post-operative forced expiratory volume (FEV) and forced vital capacity (FVC) were included. The percentage of patients with pulmonary impairment at 5 years was calculated. Repeated measures ANOVA was used to evaluate changes between pre-operative PFT and 5 years post-operative PFT and to determine whether the changes differed between curve types and approach. A sub-analysis of patients with 2 year data was performed to determine whether PFT changes were static or progressive. RESULTS: Two hundred and sixty-two patients had undergone pre-operative and 5 year post-operative PFTs. At 5 years, 42% were normal, 41% had mild impairment, and 17% had moderate-severe impairment. Overall, there was a decline in % predicted FVC (p < 0.05); FEV remained stable. There was no difference based on major curve type (p > 0.05). Anterior instrumentation cases declined significantly between pre-operative PFT and 5 years post-operative PFT (FEV: - 10% open, - 6% thoracoscopic; FVC: - 13% open, - 8% thoracoscopic) (p ≤ 0.02). The posterior cases remained stable (2% FEV, p = 0.7; - 0.6% FVC, p = 0.06). A subgroup of 90 patients with 2 year post-operative PFTs demonstrated that changes were progressive between 2 and 5 years post-operatively. The average change in FVC from 2 to 5 years was significantly different between the anterior open (- 9%) and posterior-only (0.7%) groups (p = 0.015). CONCLUSION: In patients who underwent anterior instrumentation, PFTs declined from the pre-operative to the 5 years post-operative time point. There was a progressive decline of 4-10% beyond 2 years post-operatively. Patients who underwent posterior instrumentation remained stable. These slides can be retrieved under Electronic Supplementary Material.
PURPOSE: To evaluate changes in pulmonary function tests (PFT) at 5 years post-operatively in patients with adolescent idiopathic scoliosis (AIS) and to determine whether these changes are progressive or static after 2 years. METHODS: AIS surgical patients with pre-operative and 5 year post-operative forced expiratory volume (FEV) and forced vital capacity (FVC) were included. The percentage of patients with pulmonary impairment at 5 years was calculated. Repeated measures ANOVA was used to evaluate changes between pre-operative PFT and 5 years post-operative PFT and to determine whether the changes differed between curve types and approach. A sub-analysis of patients with 2 year data was performed to determine whether PFT changes were static or progressive. RESULTS: Two hundred and sixty-two patients had undergone pre-operative and 5 year post-operative PFTs. At 5 years, 42% were normal, 41% had mild impairment, and 17% had moderate-severe impairment. Overall, there was a decline in % predicted FVC (p < 0.05); FEV remained stable. There was no difference based on major curve type (p > 0.05). Anterior instrumentation cases declined significantly between pre-operative PFT and 5 years post-operative PFT (FEV: - 10% open, - 6% thoracoscopic; FVC: - 13% open, - 8% thoracoscopic) (p ≤ 0.02). The posterior cases remained stable (2% FEV, p = 0.7; - 0.6% FVC, p = 0.06). A subgroup of 90 patients with 2 year post-operative PFTs demonstrated that changes were progressive between 2 and 5 years post-operatively. The average change in FVC from 2 to 5 years was significantly different between the anterior open (- 9%) and posterior-only (0.7%) groups (p = 0.015). CONCLUSION: In patients who underwent anterior instrumentation, PFTs declined from the pre-operative to the 5 years post-operative time point. There was a progressive decline of 4-10% beyond 2 years post-operatively. Patients who underwent posterior instrumentation remained stable. These slides can be retrieved under Electronic Supplementary Material.
Authors: Lawrence G Lenke; Peter O Newton; Michelle C Marks; Kathy M Blanke; Brenda Sides; Yongjung J Kim; Keith H Bridwell Journal: Spine (Phila Pa 1976) Date: 2004-09-15 Impact factor: 3.468
Authors: Yongjung J Kim; Lawrence G Lenke; Keith H Bridwell; Gene Cheh; Brenda Sides; Joetta Whorton Journal: Spine (Phila Pa 1976) Date: 2008-05-01 Impact factor: 3.468
Authors: E J Graham; L G Lenke; T G Lowe; R R Betz; K H Bridwell; Y Kong; K Blanke Journal: Spine (Phila Pa 1976) Date: 2000-09-15 Impact factor: 3.468
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Authors: Jayaram K Udupa; Yubing Tong; Anthony Capraro; Joseph M McDonough; Oscar H Mayer; Suzanne Ho; Paul Wileyto; Drew A Torigian; Robert M Campbell Journal: J Pediatr Orthop Date: 2020-04 Impact factor: 2.537