Jeremiah S Hinson1, Nour Al Jalbout2, Michael R Ehmann2, Eili Y Klein3. 1. Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address: hinson@jhmi.edu. 2. Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States. 3. Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States; Center for Disease Dynamics, Economics & Policy, Washington, DC, United States.
Abstract
PURPOSE: To determine the risk for acute kidney injury (AKI) attributable to intravenous contrast media (CM) administration in septic patients. MATERIALS AND METHODS: This was a single-center retrospective propensity matched cohort analysis performed in the emergency department (ED) of an academic medical center. All visits for patients ≥18 years who met sepsis diagnostic criteria and had serum creatinine (SCr) measured both on arrival to the ED and again 48 to 72 h later were included. Of 4171 visits, 1464 patients underwent contrast-enhanced CT (CECT), 976 underwent unenhanced CT and 1731 underwent no CT at all. RESULTS: The primary outcome was incidence of AKI. Logistic regression and between-groups odds ratios with and without propensity-score matching were used to test for an independent association between CM administration and AKI. Incidence of AKI was 7.2%, 9.4% and 9.7% in those who underwent CECT, unenhanced CT and no CT. CM administration was not associated with increased incidence of AKI. CONCLUSIONS: Sepsis is a medical emergency proven to benefit from early diagnosis and rapid initiation of treatment, which is often aided by CECT. Our findings argue against withholding CM for fear of precipitating AKI in potentially septic patients.
PURPOSE: To determine the risk for acute kidney injury (AKI) attributable to intravenous contrast media (CM) administration in septic patients. MATERIALS AND METHODS: This was a single-center retrospective propensity matched cohort analysis performed in the emergency department (ED) of an academic medical center. All visits for patients ≥18 years who met sepsis diagnostic criteria and had serum creatinine (SCr) measured both on arrival to the ED and again 48 to 72 h later were included. Of 4171 visits, 1464 patients underwent contrast-enhanced CT (CECT), 976 underwent unenhanced CT and 1731 underwent no CT at all. RESULTS: The primary outcome was incidence of AKI. Logistic regression and between-groups odds ratios with and without propensity-score matching were used to test for an independent association between CM administration and AKI. Incidence of AKI was 7.2%, 9.4% and 9.7% in those who underwent CECT, unenhanced CT and no CT. CM administration was not associated with increased incidence of AKI. CONCLUSIONS:Sepsis is a medical emergency proven to benefit from early diagnosis and rapid initiation of treatment, which is often aided by CECT. Our findings argue against withholding CM for fear of precipitating AKI in potentially septic patients.
Authors: Mikal Obed; Maria Magdalena Gabriel; Eva Dumann; Clara Vollmer Barbosa; Karin Weißenborn; Bernhard Magnus Wilhelm Schmidt Journal: Eur Radiol Date: 2022-06-21 Impact factor: 5.315
Authors: Peter Pickkers; Michael Darmon; Eric Hoste; Michael Joannidis; Matthieu Legrand; Marlies Ostermann; John R Prowle; Antoine Schneider; Miet Schetz Journal: Intensive Care Med Date: 2021-07-02 Impact factor: 17.440