Jordi Caballé-Serrano1, Yusra Abdeslam-Mohamed2, Antonio Munar-Frau3, Masako Fujioka-Kobayashi4, Federico Hernández-Alfaro5, Richard Miron6. 1. Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain; Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Switzerland; Robert K. Schenk Laboratory of Oral Histology, School of Dental Medicine, University of Bern, Switzerland. Electronic address: jordicase@uic.es. 2. Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. Electronic address: yusraabdeslam@gmail.com. 3. Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. Electronic address: tmunar@uic.es. 4. Department of Craniomaxillofacial Surgery, University of Bern, Bern, Switzerland. Electronic address: masako@tokushima-u.ac.jp. 5. Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. Electronic address: h.alfaro@uic.es. 6. Department of Craniomaxillofacial Surgery, University of Bern, Bern, Switzerland. Electronic address: richard.miron@zmk.unibe.ch.
Abstract
OBJECTIVES: Guided bone / tissue regeneration (GBR/GTR) procedures are necessary to improve conditions for implant placement. These techniques in turn can be enhanced by using growth factors (GFs) such as bone morphogenetic protein (BMP-2) and platelet-derived growth factor (PDGF) to accelerate regeneration. The aim of the present systematic review was to evaluate the GF loading and release kinetics of barrier membranes. STUDY DESIGN: A total of 138 articles were screened in PubMed databases, and 31 meeting the inclusion criteria were included in the present systematic review. RESULTS: All the articles evaluated bio-resorbable membranes, especially collagen or polymer-based membranes. In most studies, the retention and release kinetics of osteogenic GFs such as BMP-2 and PDGF were widely investigated. Growth factors were incorporated to the membranes by soaking and incubating the membranes in GF solution, followed by lyophilization, or mixing in the polymers before evaporation. Adsorption onto the membranes depended upon the membrane materials and additional reagents such as heparin, cross-linkers and GF concentration. Interestingly, most studies showed two phases of GF release from the membranes: a first phase comprising a burst release (about 1 day), followed by a second phase characterized by slower release. Furthermore, all the studies demonstrated the controlled release of sufficient concentrations of GFs from the membranes for bioactivities. CONCLUSIONS: The adsorption and release kinetics varied among the different materials, forms and GFs. The combination of membrane materials, GFs and manufacturing methods should be considered for optimizing GBR/GTR procedures.
OBJECTIVES: Guided bone / tissue regeneration (GBR/GTR) procedures are necessary to improve conditions for implant placement. These techniques in turn can be enhanced by using growth factors (GFs) such as bone morphogenetic protein (BMP-2) and platelet-derived growth factor (PDGF) to accelerate regeneration. The aim of the present systematic review was to evaluate the GF loading and release kinetics of barrier membranes. STUDY DESIGN: A total of 138 articles were screened in PubMed databases, and 31 meeting the inclusion criteria were included in the present systematic review. RESULTS: All the articles evaluated bio-resorbable membranes, especially collagen or polymer-based membranes. In most studies, the retention and release kinetics of osteogenic GFs such as BMP-2 and PDGF were widely investigated. Growth factors were incorporated to the membranes by soaking and incubating the membranes in GF solution, followed by lyophilization, or mixing in the polymers before evaporation. Adsorption onto the membranes depended upon the membrane materials and additional reagents such as heparin, cross-linkers and GF concentration. Interestingly, most studies showed two phases of GF release from the membranes: a first phase comprising a burst release (about 1 day), followed by a second phase characterized by slower release. Furthermore, all the studies demonstrated the controlled release of sufficient concentrations of GFs from the membranes for bioactivities. CONCLUSIONS: The adsorption and release kinetics varied among the different materials, forms and GFs. The combination of membrane materials, GFs and manufacturing methods should be considered for optimizing GBR/GTR procedures.
Authors: Luca Fiorillo; Gabriele Cervino; Pablo Galindo-Moreno; Alan Scott Herford; Gianrico Spagnuolo; Marco Cicciù Journal: Biomed Res Int Date: 2021-01-06 Impact factor: 3.411
Authors: Bushra Bilal; Rimsha Niazi; Sohail Nadeem; Muhammad Asim Farid; Muhammad Shahid Nazir; Toheed Akhter; Mohsin Javed; Ayesha Mohyuddin; Abdul Rauf; Zulfiqar Ali; Syed Ali Raza Naqvi; Nawshad Muhammad; Eslam B Elkaeed; Hala A Ibrahium; Nasser S Awwad; Sadaf Ul Hassan Journal: Front Chem Date: 2022-04-19 Impact factor: 5.545