| Literature DB >> 30797823 |
Yufeng Yao1, Nannan Liu2, Ziyun Zhou2, Li Shi3.
Abstract
The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens. Association studies have shown that genetic variations in ERAP1 and ERAP2 genes increase susceptibility to autoimmune diseases, infectious diseases, and cancers. Both ERAP1 and ERAP2 genes exhibit diverse polymorphisms in different populations, which may influence their susceptibly to the aforementioned diseases. In this article, we review the distribution of ERAP1 and ERAP2 gene polymorphisms in various populations; discuss the risk or protective influence of these gene polymorphisms in autoimmune diseases, infectious diseases, and cancers; and highlight how ERAP genetic variations can influence disease associations.Entities:
Keywords: Disease association; ERAP1; ERAP2; Polymorphism; Population genetic background
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Year: 2019 PMID： 30797823 DOI： 10.1016/j.humimm.2019.02.011
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850