Elnaz Rezaeiamiri1, Roodabeh Bahramsoltani2, Roja Rahimi3. 1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. 2. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Evidence-Based Medicine Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: rojarahimi@gmail.com.
Abstract
BACKGROUND & AIMS: Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting a growing number of patients all over the world. T2DM complications are positively associated with HbA1c which is a long-term glycemic marker. Medicinal plants and their isolated phytochemicals have been extensively used as dietary supplements for the management of chronic disorders including T2DM. Current paper aims to review clinical trials evaluated the effect of phytochemicals for long-term management of T2DM considering the HbA1c level. METHODS: Electronic databases including PubMed, Scopus and Cochrane were searched using the keywords "phytochemical", "extract", "herb", or "plant" and "HbA1c" or "glycosylated hemoglobin" in the title/abstract from the date of inception until May 2017. English and Persian language papers were included. References of the retrieved papers were also screened for relevant studies. RESULTS: Of 2435 studies, 39 relevant clinical trials were finally included in which phytochemicals including berberine, curcumin, catechin, silymarin, resveratrol, pycnogenol, isoflavones, lignans, isohumulone, saponins, corn bran hemicellulose and pinitol were examined. Berberine and silymarin had the strongest evidence regarding their effectiveness in long-term management of HbA1c; however, lack of enough toxicological studies suggests to stay on the safe side for the administration of these agents in diabetic patients. CONCLUSIONS: Current data regarding the efficacy of other phytochemicals are still controversial due to small follow-up period, methodological problems and small sample size. Future well-designed clinical trials are necessary to confirm the safety and efficacy of phytochemicals for long-term glycemic control of diabetic patients.
BACKGROUND & AIMS:Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting a growing number of patients all over the world. T2DM complications are positively associated with HbA1c which is a long-term glycemic marker. Medicinal plants and their isolated phytochemicals have been extensively used as dietary supplements for the management of chronic disorders including T2DM. Current paper aims to review clinical trials evaluated the effect of phytochemicals for long-term management of T2DM considering the HbA1c level. METHODS: Electronic databases including PubMed, Scopus and Cochrane were searched using the keywords "phytochemical", "extract", "herb", or "plant" and "HbA1c" or "glycosylated hemoglobin" in the title/abstract from the date of inception until May 2017. English and Persian language papers were included. References of the retrieved papers were also screened for relevant studies. RESULTS: Of 2435 studies, 39 relevant clinical trials were finally included in which phytochemicals including berberine, curcumin, catechin, silymarin, resveratrol, pycnogenol, isoflavones, lignans, isohumulone, saponins, corn bran hemicellulose and pinitol were examined. Berberine and silymarin had the strongest evidence regarding their effectiveness in long-term management of HbA1c; however, lack of enough toxicological studies suggests to stay on the safe side for the administration of these agents in diabeticpatients. CONCLUSIONS: Current data regarding the efficacy of other phytochemicals are still controversial due to small follow-up period, methodological problems and small sample size. Future well-designed clinical trials are necessary to confirm the safety and efficacy of phytochemicals for long-term glycemic control of diabeticpatients.
Authors: Lei Song; Yi Luo; Xinyue Wang; Mohammed M Almutairi; Huafeng Pan; Weirong Li; Yongqiang Liu; Qi Wang; Ming Hong Journal: Mol Med Rep Date: 2019-09-23 Impact factor: 2.952
Authors: Anna Tresserra-Rimbau; Sara Castro-Barquero; Facundo Vitelli-Storelli; Nerea Becerra-Tomas; Zenaida Vázquez-Ruiz; Andrés Díaz-López; Dolores Corella; Olga Castañer; Dora Romaguera; Jesús Vioque; Ángel María Alonso-Gómez; Julia Wärnberg; José Alfredo Martínez; Lluís Serra-Majem; Ramon Estruch; Francisco José Tinahones; José Lapetra; Xavier Pintó; Josep Antoni Tur; José López-Miranda; Laura García-Molina; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Lidia Daimiel; María Rubín-García; Josep Vidal; Alba Galdon; Emilio Ros; Francisco Javier Basterra-Gortari; Nancy Babio; José Vicente Sorlí; Álvaro Hernáez; Jadwiga Konieczna; Leyre Notario-Barandiaran; Lucas Tojal-Sierra; Jessica Pérez-López; Itziar Abete; Jacqueline Álvarez-Pérez; José Carlos Fernández-García; José Manuel Santos-Lozano; Ana Galera-Cusí; Alicia Julibert; Miguel Ruiz-Canela; Raul Martinez-Lacruz; Karla-Alejandra Pérez-Vega; Aina María Galmes-Panades; Concepción Pastor-Polo; Anai Moreno-Rodriguez; Alfredo Gea; Montserrat Fitó; Rosa María Lamuela-Raventós; Jordi Salas-Salvadó Journal: Antioxidants (Basel) Date: 2019-11-08