Sonali Gupta1, Pradeep Goyal2, Richard S Feinn3, Joseph Mattana4. 1. Department of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut. Electronic address: gupta.sonali2706@gmail.com. 2. The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut; Department of Radiology, St. Vincent's Medical Center, Bridgeport, Connecticut. 3. Department of Medical Sciences, The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut. 4. Department of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut.
Abstract
BACKGROUND: Diabetic nephropathy remains one of the most common causes of chronic kidney disease in the United States and is associated with significant morbidity and mortality. Recently, there have been emerging data highlighting the role of vitamin D and its analogue in chronic kidney disease especially diabetic nephropathy independent of its effect on bone metabolism. METHODS: This study aimed to evaluate effect of supplementing vitamin D and its analogues on halting or slowing progression of diabetic nephropathy. Electronic databases (PubMed, Scopus, Google scholar) were searched and randomized controlled trials (RCTs) that investigated the use of vitamin D and its analogs for diabetic nephropathy were studied. This meta-analysis of RCTs performed in accordance with Preferred Reporting Items for Systematic review and Meta-analysis statement. RESULTS: This meta-analysis included 9 RCTs and suggested a favorable trend with respect to an effect of vitamin D and its analogues on albuminuria though this did not reach statistical significance (MD, -0.17; 95% CI, -0.34-0.01; P = 0.06]. Serum calcium was unaffected suggesting safe use of these agents. CONCLUSIONS: Use of vitamin D and its analogues may have potential as an adjuvant therapy for reducing albuminuria and slowing progression of diabetic nephropathy but further studies are needed.
BACKGROUND:Diabetic nephropathy remains one of the most common causes of chronic kidney disease in the United States and is associated with significant morbidity and mortality. Recently, there have been emerging data highlighting the role of vitamin D and its analogue in chronic kidney disease especially diabetic nephropathy independent of its effect on bone metabolism. METHODS: This study aimed to evaluate effect of supplementing vitamin D and its analogues on halting or slowing progression of diabetic nephropathy. Electronic databases (PubMed, Scopus, Google scholar) were searched and randomized controlled trials (RCTs) that investigated the use of vitamin D and its analogs for diabetic nephropathy were studied. This meta-analysis of RCTs performed in accordance with Preferred Reporting Items for Systematic review and Meta-analysis statement. RESULTS: This meta-analysis included 9 RCTs and suggested a favorable trend with respect to an effect of vitamin D and its analogues on albuminuria though this did not reach statistical significance (MD, -0.17; 95% CI, -0.34-0.01; P = 0.06]. Serum calcium was unaffected suggesting safe use of these agents. CONCLUSIONS: Use of vitamin D and its analogues may have potential as an adjuvant therapy for reducing albuminuria and slowing progression of diabetic nephropathy but further studies are needed.
Authors: João Soares Felício; Hana Andrade de Rider Britto; Pedro Celeira Cortez; Fabrício de Souza Resende; Manuela Nascimento de Lemos; Lorena Vilhena de Moraes; Vitória Teixeira de Aquino; Fernanda de Souza Parente; Natércia Neves Marques de Queiroz; João Felício Abrahão Neto; Angélica Leite de Alcântara; Wanderson Maia da Silva; Norberto Jorge Kzan de Souza Neto; Pedro Paulo Freire Piani; Ícaro José Araújo de Souza; Lilian de Souza D'Albuquerque Silva; Maria Clara Neres Iunes de Oliveira; Nivin Mazen Said; Gabriela Nascimento de Lemos; Franciane Trindade Cunha de Melo; Daniela Lopes Gomes; Ana Carolina Contente Braga de Souza; Melissa de Sá Oliveira Dos Reis; Valéria Suênya Galvão Leal; Isabel Jane Campos Lobato; Karem Miléo Felício Journal: Front Endocrinol (Lausanne) Date: 2021-10-07 Impact factor: 5.555