Literature DB >> 3079735

Neutralization of lymphokine-mediated antirickettsial activity of fibroblasts and macrophages with monoclonal antibody specific for murine interferon gamma.

T R Jerrells, J Turco, H H Winkler, G L Spitalny.   

Abstract

Lymphokine-mediated inhibition of Rickettsia prowazekii multiplication in L929 fibroblasts was eliminated by treatment of the lymphokine with a monoclonal antibody specific for interferon-gamma. Soluble monoclonal antibody and antibody conjugated to Sepharose beads were equally effective. Macrophage activation to limit the multiplication of Rickettsia conorii was eliminated with antibody-conjugated beads; however, neutralization of the ability to activate macrophages with soluble antibody was not complete and required more antibody than did neutralization of antiviral activity.

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Year:  1986        PMID： 3079735      PMCID： PMC261111          DOI： 10.1128/iai.51.1.355-359.1986

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Host defenses in experimental scrub typhus: role of normal and activated macrophages.

Authors:  C A Nacy; J V Osterman
Journal:  Infect Immun       Date:  1979-11       Impact factor: 3.441

2.  Experimental infection of mouse peritoneal mesothelium with scrub typhus rickettsiae: an ultrastructural study.

Authors:  E P Ewing; A Takeuchi; A Shirai; J V Osterman
Journal:  Infect Immun       Date:  1978-03       Impact factor: 3.441

3.  Production of high-titered interferon in cultures of human diploid cells.

Authors:  E A Havell; J Vilcek
Journal:  Antimicrob Agents Chemother       Date:  1972-12       Impact factor: 5.191

4.  Plaque assay and cloning of scrub typhus rickettsiae in irradiated L-929 cells.

Authors:  S C Oaks; J V Osterman; F M Hetrick
Journal:  J Clin Microbiol       Date:  1977-07       Impact factor: 5.948

5.  Mechanisms of immunity in typhus infection: adoptive transfer of immunity to Rickettsia mooseri.

Authors:  J R Murphy; C G Wisseman; P Fiset
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

6.  Macrophages in resistance to rickettsial infection: macrophage activation in vitro for killing of Rickettsia tsutsugamushi.

Authors:  C A Nacy; M S Meltzer
Journal:  J Immunol       Date:  1979-12       Impact factor: 5.422

7.  Host defenses in experimental scrub typhus: role of cellular immunity in heterologous protection.

Authors:  A Shirai; P J Catanzaro; S M Phillips; J V Osterman
Journal:  Infect Immun       Date:  1976-07       Impact factor: 3.441

8.  Host defenses in experimental scrub typhus: delayed-type hypersensitivity responses of inbred mice.

Authors:  T R Jerrells; J V Osterman
Journal:  Infect Immun       Date:  1982-01       Impact factor: 3.441

9.  Immune responses to Rickettsia akari infection in congenitally athymic nude mice.

Authors:  R H Kenyon; C E Pedersen
Journal:  Infect Immun       Date:  1980-05       Impact factor: 3.441

10.  Enhanced production of murine interferon gamma by T cells generated in response to bacterial infection.

Authors:  E A Havell; G L Spitalny; P J Patel
Journal:  J Exp Med       Date:  1982-07-01       Impact factor: 14.307
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  12 in total

1.  Establishment and characterization of a T-cell line specific for Rickettsia tsutsugamushi.

Authors:  K Kodama; S Kawamura; M Yasukawa; Y Kobayashi
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441

2.  Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes.

Authors:  D M Mwangi; S M Mahan; J K Nyanjui; E L Taracha; D J McKeever
Journal:  Infect Immun       Date:  1998-05       Impact factor: 3.441

3.  Comparative susceptibility to mouse interferons of Rickettsia tsutsugamushi strains with different virulence in mice and of Rickettsia rickettsii.

Authors:  B Hanson
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

4.  Comparison of properties of virulent, avirulent, and interferon-resistant Rickettsia prowazekii strains.

Authors:  J Turco; H H Winkler
Journal:  Infect Immun       Date:  1991-05       Impact factor: 3.441

5.  Gamma interferon as a crucial host defense against Rickettsia conorii in vivo.

Authors:  H Li; T R Jerrells; G L Spitalny; D H Walker
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

6.  Synthesis of DNA, rRNA, and protein by Rickettsia prowazekii growing in untreated or gamma interferon-treated mouse L929 cells.

Authors:  Q Gao; J Turco; H H Winkler
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

7.  Susceptibility of Rickettsia tsutsugamushi Gilliam to gamma interferon in cultured mouse cells.

Authors:  B Hanson
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

8.  Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease.

Authors:  H M Feng; V L Popov; D H Walker
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

9.  Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide.

Authors:  H M Feng; D H Walker
Journal:  Am J Pathol       Date:  1993-10       Impact factor: 4.307

10.  Murine T-cell response to native and recombinant protein antigens of Rickettsia tsutsugamushi.

Authors:  C J Hickman; C K Stover; S W Joseph; E V Oaks
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441
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