| Literature DB >> 3079713 |
S J Prowse, D Bellgrau, K J Lafferty.
Abstract
Transplantation of cultured islet and pituitary tissue from PVG (RT1c) donors to major histocompatibility complex-incompatible BB/D recipients (RT1u) results in tissue-specific destruction of the grafted islets but not of the pituitary. We interpret this response as disease occurrence in the MHC-incompatible islet graft. Islet damage is associated with eosinophil and mast cell accumulation in and around the grafted tissue. Antibody deposition is also present in tissues of the BB rat. This is suggestive of an antibody-mediated allergic reaction.Entities:
Mesh：
Year: 1986 PMID： 3079713 DOI： 10.2337/diab.35.1.110
Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461