Literature DB >> 30796959

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies.

Kerstin Heurling1, Nicholas J Ashton2, Antoine Leuzy3, Eduardo R Zimmer4, Kaj Blennow5, Henrik Zetterberg6, Jonas Eriksson7, Mark Lubberink8, Michael Schöll9.   

Abstract

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Biomarkers; Position emission tomography; SV2A; Synaptopathies

Mesh：

Substances：

Year:  2019        PMID： 30796959     DOI： 10.1016/j.mcn.2019.02.001

Source DB:  PubMed          Journal:  Mol Cell Neurosci        ISSN： 1044-7431            Impact factor:   4.314


  15 in total

1.  Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample.

Authors:  Alfredo Ramos-Miguel; Andrea A Jones; Vladislav A Petyuk; Vilte E Barakauskas; Alasdair M Barr; Sue E Leurgans; Philip L De Jager; Kaitlin B Casaletto; Julie A Schneider; David A Bennett; William G Honer
Journal:  Acta Neuropathol       Date:  2021-03-01       Impact factor: 17.088

Review 2.  The role of neuroimaging in Parkinson's disease.

Authors:  Natasha S R Bidesi; Ida Vang Andersen; Albert D Windhorst; Vladimir Shalgunov; Matthias M Herth
Journal:  J Neurochem       Date:  2021-10-03       Impact factor: 5.546

3.  Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task.

Authors:  Kelly Smart; Heather Liu; David Matuskey; Ming-Kai Chen; Kristen Torres; Nabeel Nabulsi; David Labaree; Jim Ropchan; Ansel T Hillmer; Yiyun Huang; Richard E Carson
Journal:  J Cereb Blood Flow Metab       Date:  2020-08-05       Impact factor: 6.200

Review 4.  Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review.

Authors:  Breton M Asken; Gil D Rabinovici
Journal:  Acta Neuropathol Commun       Date:  2021-05-22       Impact factor: 7.801

5.  Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive-compulsive disorder-like behaviour.

Authors:  Dorien Glorie; Jeroen Verhaeghe; Alan Miranda; Stef De Lombaerde; Sigrid Stroobants; Steven Staelens
Journal:  EJNMMI Res       Date:  2020-11-13       Impact factor: 3.138

Review 6.  Inhibiting Epileptiform Activity in Cognitive Disorders: Possibilities for a Novel Therapeutic Approach.

Authors:  Andras Attila Horvath; Emoke Anna Csernus; Sara Lality; Rafal M Kaminski; Anita Kamondi
Journal:  Front Neurosci       Date:  2020-10-15       Impact factor: 4.677

7.  In vivo tau pathology is associated with synaptic loss and altered synaptic function.

Authors:  Emma M Coomans; Deborah N Schoonhoven; Hayel Tuncel; Sander C J Verfaillie; Emma E Wolters; Ronald Boellaard; Rik Ossenkoppele; Anouk den Braber; Wiep Scheper; Patrick Schober; Steven P Sweeney; J Michael Ryan; Robert C Schuit; Albert D Windhorst; Frederik Barkhof; Philip Scheltens; Sandeep S V Golla; Arjan Hillebrand; Alida A Gouw; Bart N M van Berckel
Journal:  Alzheimers Res Ther       Date:  2021-02-05       Impact factor: 6.982

8.  Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

Authors:  Maura Malpetti; Negin Holland; P Simon Jones; Rong Ye; Thomas E Cope; Tim D Fryer; Young T Hong; George Savulich; Timothy Rittman; Luca Passamonti; Elijah Mak; Franklin I Aigbirhio; John T O'Brien; James B Rowe
Journal:  Ann Clin Transl Neurol       Date:  2021-06-16       Impact factor: 5.430

9.  Evaluating the In Vivo Specificity of [18F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.

Authors:  Maria Elisa Serrano; Guillaume Becker; Mohamed Ali Bahri; Alain Seret; Nathalie Mestdagh; Joël Mercier; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Journal:  Molecules       Date:  2019-05-01       Impact factor: 4.411

10.  Improved synthesis of SV2A targeting radiotracer [11C]UCB-J.

Authors:  Johanna Rokka; Eva Schlein; Jonas Eriksson
Journal:  EJNMMI Radiopharm Chem       Date:  2019-11-29
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