Literature DB >> 30793233

Comparative Analysis of Secretome of Human Umbilical Cord- and Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells.

Yu A Romanov1,2, N E Volgina3, V V Vtorushina3, A Yu Romanov3, T N Dugina4, N V Kabaeva5, G T Sukhikh3.   

Abstract

Production of cytokines and growth factors by cultured human umbilical cord tissue- and bone marrow-derived multipotent mesenchymal stromal cells was measured by multiplex analysis. In most cases, the concentrations of bioactive factors in the culture medium conditioned by umbilical cord-derived cells was ten- to hundred-times higher than in the medium conditioned by bone marrow-derived cells. These results suggest that both multipotent mesenchymal stromal cells from the umbilical cord and cell-free products can have more pronounced therapeutic effect in comparison with mesenchymal stromal cells obtained from "adult" sources.

Entities:  

Keywords:  bone marrow; multipotent mesenchymal stromal cells; secretome; umbilical cord

Mesh：

Year:  2019        PMID： 30793233     DOI： 10.1007/s10517-019-04388-1

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  Functional Activity of Non-Proliferating Mesenchymal Stromal Cells Cultured at Different Densities.

Authors:  M I Ezdakova; K V Zornikova; S V Buravkov; E R Andreeva
Journal:  Bull Exp Biol Med       Date:  2021-03-16       Impact factor: 0.804

2.  Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions.

Authors:  Marek Kukumberg; Tatsanee Phermthai; Suparat Wichitwiengrat; Xiaoyuan Wang; Subramanian Arjunan; Suet Yen Chong; Chui-Yee Fong; Jiong-Wei Wang; Abdul Jalil Rufaihah; Citra Nurfarah Zaini Mattar
Journal:  Sci Rep       Date:  2021-01-08       Impact factor: 4.379

Review 3.  Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine.

Authors:  Alberto González-González; Daniel García-Sánchez; Monica Dotta; José C Rodríguez-Rey; Flor M Pérez-Campo
Journal:  World J Stem Cells       Date:  2020-12-26       Impact factor: 5.326

Review 4.  The therapeutic potential of mesenchymal stem cells in treating osteoporosis.

Authors:  Tianning Chen; Tieyi Yang; Weiwei Zhang; Jin Shao
Journal:  Biol Res       Date:  2021-12-20       Impact factor: 5.612

Review 5.  Mesenchymal Stem Cell Derived Extracellular Vesicles for Repairing the Neurovascular Unit after Ischemic Stroke.

Authors:  Courtney Davis; Sean I Savitz; Nikunj Satani
Journal:  Cells       Date:  2021-03-31       Impact factor: 6.600
  5 in total

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