Christian Henker1, Thomas Kriesen2, Björn Schneider3, Änne Glass4, Moritz Scherer5, Sönke Langner6, Andreas Erbersdobler3, Jürgen Piek2. 1. Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany. Electronic address: christian.henker@med.uni-rostock.de. 2. Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany. 3. Institute for Pathology, University Medicine of Rostock, Rostock, Germany. 4. Institute for Biostatistics and Informatics in Medicine, University Medicine of Rostock, Rostock, Germany. 5. Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany. 6. Institute for Diagnostic and Interventional Radiology, University Medicine of Rostock, Rostock, Germany.
Abstract
OBJECTIVE: Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. METHODS: In our retrospective study, only isocitrate dehydrogenase IDH wild-type glioblastoma was included (n = 152). Ki-67 index was quantified via immunohistochemistry. On all pretreatment MRI, tumor compartments (tumor, necrosis, and edema) were volumetrically assessed. An OS subpopulation was filtered from the total cohort (residual tumor volume ≤2 cm3). In addition, a propensity score matching was executed. RESULTS: All volumetric assessed tumor volumes correlated with each other (P ≤ 0.011), although the Ki-67 index showed no correlation with any of the measured volumes. Concerning the OS, a cutoff value of 20% for the Ki-67 index showed a significant influence on patients' OS in multivariate analysis (P = 0.043). CONCLUSIONS: The unique appearance of every glioblastoma on MRI seems to be independent of the Ki-67 index. Furthermore, the Ki-67 index did show a distinct prognostic value for OS within our cohort at a cutoff value of 20% for Ki-67.
OBJECTIVE: Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. METHODS: In our retrospective study, only isocitrate dehydrogenase IDH wild-type glioblastoma was included (n = 152). Ki-67 index was quantified via immunohistochemistry. On all pretreatment MRI, tumor compartments (tumor, necrosis, and edema) were volumetrically assessed. An OS subpopulation was filtered from the total cohort (residual tumor volume ≤2 cm3). In addition, a propensity score matching was executed. RESULTS: All volumetric assessed tumor volumes correlated with each other (P ≤ 0.011), although the Ki-67 index showed no correlation with any of the measured volumes. Concerning the OS, a cutoff value of 20% for the Ki-67 index showed a significant influence on patients' OS in multivariate analysis (P = 0.043). CONCLUSIONS: The unique appearance of every glioblastoma on MRI seems to be independent of the Ki-67 index. Furthermore, the Ki-67 index did show a distinct prognostic value for OS within our cohort at a cutoff value of 20% for Ki-67.
Authors: Ricardo Caramanti; Raysa M Aprígio; Carlos E D Aglio Rocha; Dionei F Morais; Mário J Góes; Feres Chaddad-Neto; Waldir A Tognola Journal: Cureus Date: 2022-04-18
Authors: António G P Bastos; Bruno Carvalho; Roberto Silva; Dina Leitão; Paulo Linhares; Rui Vaz; Jorge Lima Journal: Front Oncol Date: 2022-09-06 Impact factor: 5.738