Dhayana Dallmeier1,2, Ulrike Braisch1,2,3, Kilian Rapp4, Jochen Klenk3,4, Dietrich Rothenbacher3, Michael Denkinger1,2. 1. Agaplesion Bethesda Clinic, Ulm, Germany. 2. Geriatric Center Ulm/Alb-Donau, Ulm University, Ulm, Germany. 3. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany. 4. Department of Clinical Gerontology,Robert Bosch Hospital, Stuttgart, Germany.
Abstract
BACKGROUND: Considering that mortality rate and deficit accumulation varies considerably in men and women we performed a sex-stratified analysis of the association between an estimated frailty index (eFI) with six-year mortality in the Activity and Function in the Elderly (ActiFE) Study. METHODS: We constructed an eFI using a score (0 (no deficit) to 1 (deficit)) from 32 baseline items representing multiple domains. eFI represents the sum of all scores divided by 32. Cox proportional hazards models adjusted for age, smoking, alcohol intake and education were used to evaluate this association. RESULTS: Among 1204 participants (57.5% men) 18.5% men and 26.0% women were frail (eFI≥0.2) with an age-adjusted mean eFI of 0.13 [95% CI 0.12, 0.13] and 0.15 [95% CI 0.15, 0.16], respectively. Mortality rate in men (146 deaths) was 34.4 [95% CI 29.3, 40.5] and in women (50 deaths) 15.1 [95% CI 11.5, 19.9] per 1000 person-years. A 0.1 increment of eFI was associated with a hazard ratio (HR) of 1.94 [95% CI 1.60, 2.35] in men and 2.06 [95% CI 1.58, 2.69] in women. Frail versus non-frail men and women had a HR of 2.46 [95% CI 1.74, 3.48], and 2.98 [95% CI 1.55, 5.70], respectively. We detected sex differences in the order of the eight common contributor items to the eFI. CONCLUSIONS: We observed a statistically significant difference for the age-adjusted eFI and the frailty prevalence in men and women. However, our analysis does not suggest the presence of effect modification by sex in the association with mortality.
BACKGROUND: Considering that mortality rate and deficit accumulation varies considerably in men and women we performed a sex-stratified analysis of the association between an estimated frailty index (eFI) with six-year mortality in the Activity and Function in the Elderly (ActiFE) Study. METHODS: We constructed an eFI using a score (0 (no deficit) to 1 (deficit)) from 32 baseline items representing multiple domains. eFI represents the sum of all scores divided by 32. Cox proportional hazards models adjusted for age, smoking, alcohol intake and education were used to evaluate this association. RESULTS: Among 1204 participants (57.5% men) 18.5% men and 26.0% women were frail (eFI≥0.2) with an age-adjusted mean eFI of 0.13 [95% CI 0.12, 0.13] and 0.15 [95% CI 0.15, 0.16], respectively. Mortality rate in men (146 deaths) was 34.4 [95% CI 29.3, 40.5] and in women (50 deaths) 15.1 [95% CI 11.5, 19.9] per 1000 person-years. A 0.1 increment of eFI was associated with a hazard ratio (HR) of 1.94 [95% CI 1.60, 2.35] in men and 2.06 [95% CI 1.58, 2.69] in women. Frail versus non-frail men and women had a HR of 2.46 [95% CI 1.74, 3.48], and 2.98 [95% CI 1.55, 5.70], respectively. We detected sex differences in the order of the eight common contributor items to the eFI. CONCLUSIONS: We observed a statistically significant difference for the age-adjusted eFI and the frailty prevalence in men and women. However, our analysis does not suggest the presence of effect modification by sex in the association with mortality.
Authors: Nada Almohaisen; Matthew Gittins; Chris Todd; Jana Sremanakova; Anne Marie Sowerbutts; Amal Aldossari; Asrar Almutairi; Debra Jones; Sorrel Burden Journal: Nutrients Date: 2022-04-07 Impact factor: 6.706
Authors: Felicia R Simpson; Nicholas M Pajewski; Barbara Nicklas; Stephen Kritchevsky; Alain Bertoni; Frank Ingram; Daniel Ojeranti; Mark A Espeland Journal: J Gerontol A Biol Sci Med Sci Date: 2020-09-25 Impact factor: 6.053