Literature DB >> 30789266

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H.

Devin M Ferguson1, Christian A Malapit1, James R Bour1, Melanie S Sanford1.   

Abstract

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(P tBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

Entities:  

Year:  2019        PMID： 30789266     DOI： 10.1021/acs.joc.9b00324

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Palladium-Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.

Authors:  Kyoungmin Choi; Michael G Mormino; Eric D Kalkman; John Park; John F Hartwig
Journal:  Angew Chem Int Ed Engl       Date:  2022-09-07       Impact factor: 16.823

2.  Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay.

Authors:  Aijie Cai; Wenhao Yan; Xiaojun Zeng; Samson B Zacate; Tzu-Hsuan Chao; Jeanette A Krause; Mu-Jeng Cheng; Wei Liu
Journal:  Nat Commun       Date:  2021-06-01       Impact factor: 14.919

3.  Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane.

Authors:  Raffaele Senatore; Monika Malik; Markus Spreitzer; Wolfgang Holzer; Vittorio Pace
Journal:  Org Lett       Date:  2020-01-31       Impact factor: 6.005

4.  Pd-Catalyzed Difluoromethylations of Aryl Boronic Acids, Halides, and Pseudohalides with ICF2 H Generated ex Situ.

Authors:  Oliver R Gedde; Andreas Bonde; Peter I Golbaekdal; Troels Skrydstrup
Journal:  Chemistry       Date:  2022-05-03       Impact factor: 5.020
  4 in total

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