J Qiu1, G Che2, F Liu3, X Sha4, S Ju5, H Ma6, L Feng7. 1. Department of Oncology, The Affiliated Suzhou Hospital (West District) of Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, 215153, China. 2. Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China. 3. Department of Cardiothoracic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, 215153, Jiangsu, China. 4. Department of Oncology, Hongze Huaian District People's Hospital, Huaian, 223100, Jiangsu, China. 5. Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215006, Jiangsu, China. 6. Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China. mahaiqing@mail.sysu.edu.cn. 7. Department of Oncology, The Affiliated Suzhou Hospital (West District) of Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, 215153, China. 13862578628@163.com.
Abstract
OBJECTIVE: In this study, we aimed to discuss the clinical significance of CD4+CD25hiCD127low regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC). METHODS: Sixty patients with NSCLC and 35 healthy controls were studied. Peripheral blood CD4+CD25hiCD127lowTregs, CD4+CD25hiT cells, and CD4+T cells were measured with flow cytometric analysis, and results were compared between the groups. RESULTS: Compared with healthy people, CD4+CD25hiCD127low Tregs and CD4+CD25hi T cells significantly increased in patients with NSCLC, while CD4+ T cell proportions decreased. CONCLUSIONS: CD4+CD25 hi CD127low Treg detection in the peripheral blood of NSCLC patients is highly significant, in that it provides additional knowledge to guide the selection of individualized treatment plans for patients with NSCLC.
OBJECTIVE: In this study, we aimed to discuss the clinical significance of CD4+CD25hiCD127low regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC). METHODS: Sixty patients with NSCLC and 35 healthy controls were studied. Peripheral blood CD4+CD25hiCD127lowTregs, CD4+CD25hiT cells, and CD4+T cells were measured with flow cytometric analysis, and results were compared between the groups. RESULTS: Compared with healthy people, CD4+CD25hiCD127low Tregs and CD4+CD25hi T cells significantly increased in patients with NSCLC, while CD4+ T cell proportions decreased. CONCLUSIONS:CD4+CD25 hi CD127low Treg detection in the peripheral blood of NSCLCpatients is highly significant, in that it provides additional knowledge to guide the selection of individualized treatment plans for patients with NSCLC.
Entities:
Keywords:
CD4+CD25hiCD127lowTreg; CD4+CD25hiT cells; CD4+T cells; Non-small cell lung cancer
Authors: Edward Y Woo; Heidi Yeh; Christina S Chu; Katia Schlienger; Richard G Carroll; James L Riley; Larry R Kaiser; Carl H June Journal: J Immunol Date: 2002-05-01 Impact factor: 5.422
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