Literature DB >> 30788415

BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression.

Yilei Zhang1, Li Zhuang1, Boyi Gan1.   

Abstract

The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.

Entities:  

Keywords:  BAP1; H2A ubiquitination; SLC7A11; ferroptosis; metabolism; tumor suppression

Year:  2018        PMID： 30788415      PMCID： PMC6370386          DOI： 10.1080/23723556.2018.1536845

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  31 in total

Review 1.  Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis.

Authors:  Annadurai Anandhan; Matthew Dodson; Cody J Schmidlin; Pengfei Liu; Donna D Zhang
Journal:  Cell Chem Biol       Date:  2020-04-09       Impact factor: 8.116

2.  BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.

Authors:  Lauren E Langbein; Rayan El Hajjar; Shen He; Eleonora Sementino; Zhijiu Zhong; Wei Jiang; Benjamin E Leiby; Li Li; Robert G Uzzo; Joseph R Testa; Haifeng Yang
Journal:  Cancer Lett       Date:  2022-08-20       Impact factor: 9.756

3.  From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit.

Authors:  Toni K Choueiri; Laurence Albiges; Michael B Atkins; Ziad Bakouny; Gennady Bratslavsky; David A Braun; Naomi B Haas; John B A G Haanen; A Ari Hakimi; Michael A S Jewett; Eric Jonasch; William G Kaelin; Payal Kapur; Chris Labaki; Bryan Lewis; David F McDermott; Sumanta K Pal; Kevin Pels; Susan Poteat; Thomas Powles; W Kimryn Rathmell; Brian I Rini; Sabina Signoretti; Nizar M Tannir; Robert G Uzzo; Hans J Hammers
Journal:  Clin Cancer Res       Date:  2022-03-01       Impact factor: 13.801

Review 4.  Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases.

Authors:  Xiaoting Dang; Xuejie Huan; Xixun Du; Xi Chen; Mingxia Bi; Chunling Yan; Qian Jiao; Hong Jiang
Journal:  Neurosci Bull       Date:  2022-04-28       Impact factor: 5.271

5.  The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.

Authors:  Guang Lei; Yilei Zhang; Pranavi Koppula; Xiaoguang Liu; Jie Zhang; Steven H Lin; Jaffer A Ajani; Qin Xiao; Zhongxing Liao; Hui Wang; Boyi Gan
Journal:  Cell Res       Date:  2020-01-16       Impact factor: 25.617

6.  Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity.

Authors:  Guang Lei; Yilei Zhang; Ting Hong; Xudong Zhang; Xiaoguang Liu; Chao Mao; Yuelong Yan; Pranavi Koppula; Weijie Cheng; Anil K Sood; Jinsong Liu; Boyi Gan
Journal:  Oncogene       Date:  2021-04-29       Impact factor: 9.867

7.  RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11.

Authors:  Wenjing Zhang; Yu Sun; Lu Bai; Lili Zhi; Yun Yang; Qingzhi Zhao; Chaoqun Chen; Yangfan Qi; Wenting Gao; Wenxia He; Luning Wang; Dan Chen; Shujun Fan; Huan Chen; Hai-Long Piao; Qinglong Qiao; Zhaochao Xu; Jinrui Zhang; Jinyao Zhao; Sirui Zhang; Yue Yin; Chao Peng; Xiaoling Li; Quentin Liu; Han Liu; Yang Wang
Journal:  J Clin Invest       Date:  2021-11-15       Impact factor: 14.808

8.  lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis.

Authors:  Yanni Yang; Wenlin Tai; Nihong Lu; Ting Li; Yongjun Liu; Wenjuan Wu; Zhengkun Li; Lin Pu; Xiaoyuan Zhao; Tao Zhang; Zhaoxing Dong
Journal:  Aging (Albany NY)       Date:  2020-05-26       Impact factor: 5.682

9.  MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.

Authors:  Divya Venkatesh; Nicholas A O'Brien; Fereshteh Zandkarimi; David R Tong; Michael E Stokes; Denise E Dunn; Everett S Kengmana; Allegra T Aron; Alyssa M Klein; Joleen M Csuka; Sung-Hwan Moon; Marcus Conrad; Christopher J Chang; Donald C Lo; Angelo D'Alessandro; Carol Prives; Brent R Stockwell
Journal:  Genes Dev       Date:  2020-02-20       Impact factor: 11.361

10.  Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

Authors:  Xiaoguang Liu; Kellen Olszewski; Yilei Zhang; Esther W Lim; Jiejun Shi; Xiaoshan Zhang; Jie Zhang; Hyemin Lee; Pranavi Koppula; Guang Lei; Li Zhuang; M James You; Bingliang Fang; Wei Li; Christian M Metallo; Masha V Poyurovsky; Boyi Gan
Journal:  Nat Cell Biol       Date:  2020-03-30       Impact factor: 28.824
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