Elko Randrianarisoa1,2,3, Angela Lehn-Stefan1,2,3, Anja Hieronimus1,2,3, Roderich Rietig1,2,3, Andreas Fritsche1,2,3, Jürgen Machann2,3,4, Bernd Balletshofer1, Hans-Ulrich Häring1,2,3, Norbert Stefan1,2,3, Kilian Rittig1,5. 1. Department of Internal Medicine IV, Division of Endocrinology and Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University Hospital of Tübingen. 2. Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen. 3. German Center for Diabetes Research (DZD). 4. Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen. 5. Department of Internal Medicine, Deutsches Rotes Kreuz Kliniken Berlin.
Abstract
AIM: The visceral adiposity index (VAI) has been proposed as an estimate of visceral adipose tissue (VAT) mass and as an indicator of VAT dysfunction. Both parameters are associated with cardiometabolic risk, including insulin resistance. In this study, we investigated whether VAI is associated with subclinical atherosclerosis in subjects who were free of cardiovascular disease but were at risk of developing diabetes mellitus. METHODS: A total of 731 adults with a median age of 47 years old without diabetes mellitus were included in this cross-sectional study. The anthropometric data, blood pressure, and lipid profiles of 398 women and 333 men were measured. All subjects underwent an oral glucose tolerance test, and carotid intima-media thickness (cIMT) was evaluated by ultrasound. Insulin resistance was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR). RESULTS: VAI and HOMA-IR (ßst=0.44, p＜0.0001), VAI and cIMT (ßst=0.17, p＜0.0001), and HOMA-IR and cIMT (ßst=0.09, p=0.0127) were correlated with each other. After adjusting for cofounding variables, VAI is still correlated with HOMA-IR (ßst=0.42, p＜0.0001). Furthermore, VAI (ßst=0.07, p=0.0392) but not HOMA-IR (ßst=0.03, p=0.37) was correlated with cIMT independently of other established cardiovascular risk factors. CONCLUSION: The calculation of VAI may provide a better estimation of subclinical atherosclerosis than the calculation of HOMA-IR.
AIM: The visceral adiposity index (VAI) has been proposed as an estimate of visceral adipose tissue (VAT) mass and as an indicator of VAT dysfunction. Both parameters are associated with cardiometabolic risk, including insulin resistance. In this study, we investigated whether VAI is associated with subclinical atherosclerosis in subjects who were free of cardiovascular disease but were at risk of developing diabetes mellitus. METHODS: A total of 731 adults with a median age of 47 years old without diabetes mellitus were included in this cross-sectional study. The anthropometric data, blood pressure, and lipid profiles of 398 women and 333 men were measured. All subjects underwent an oral glucose tolerance test, and carotid intima-media thickness (cIMT) was evaluated by ultrasound. Insulin resistance was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR). RESULTS:VAI and HOMA-IR (ßst=0.44, p＜0.0001), VAI and cIMT (ßst=0.17, p＜0.0001), and HOMA-IR and cIMT (ßst=0.09, p=0.0127) were correlated with each other. After adjusting for cofounding variables, VAI is still correlated with HOMA-IR (ßst=0.42, p＜0.0001). Furthermore, VAI (ßst=0.07, p=0.0392) but not HOMA-IR (ßst=0.03, p=0.37) was correlated with cIMT independently of other established cardiovascular risk factors. CONCLUSION: The calculation of VAI may provide a better estimation of subclinical atherosclerosis than the calculation of HOMA-IR.
Authors: Ladislav Štěpánek; Dagmar Horáková; Ľubica Cibičková; Helena Vaverková; David Karásek; Marie Nakládalová; Jana Zapletalová Journal: Medicina (Kaunas) Date: 2019-08-29 Impact factor: 2.430
Authors: Mehmet Giray Sönmez; Muzaffer Tansel Kılınç; İbrahim Göksoy; Betül Kozanhan; Arif Aydın; Mehmet Balasar; Selçuk Güven Journal: Cent European J Urol Date: 2022-04-13