| Literature DB >> 30784775 |
Xu Zhang1, Takayuki Fujii2, Hidenori Ogata3, Ryo Yamasaki4, Katsuhisa Masaki5, Yiwen Cui6, Takuya Matsushita7, Noriko Isobe8, Jun-Ichi Kira9.
Abstract
Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Cluster analyses disclosed two major clusters: one mainly consisted of IHP and the other of OND, suggesting a unique cytokine profile in IHP.Entities:
Keywords: Cerebrospinal fluid; Cytokine; Hypertrophic pachymeningitis; Type 2 helper T cell
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Year: 2019 PMID： 30784775 DOI： 10.1016/j.jneuroim.2019.01.010
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478