| Literature DB >> 30784574 |
Janne Ruotsalainen1, Thomas Tüting2.
Abstract
Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-γ-dependent T cell hyperactivation and death and thus favors tumor progression.Entities:
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Year: 2019 PMID： 30784574 DOI： 10.1016/j.immuni.2019.01.016
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745