| Literature DB >> 30784281 |
H Y Mao1,2, S P Liu3, G M Kong2, Y Xu1, Y C Xu1, G Z Sun2, Z Wang1, F Han1, J D Tong1, P Bo2.
Abstract
Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA could inhibit proliferation, induce G1/S arrest, and promote cell apoptosis. Fibulin-3 overexpression further suppressed the invasion and metastasis of CRC. These effects were regulated through the AKT/mTOR signaling pathway.Entities:
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Year: 2019 PMID： 30784281 DOI： 10.4149/neo_2018_180703N441
Source DB: PubMed Journal: Neoplasma ISSN： 0028-2685 Impact factor: 2.575