| Literature DB >> 30784060 |
Takako Miyamura1,2, Hiroshi Moritake3, Hideki Nakayama4, Shiro Tanaka5, Daisuke Tomizawa6, Norio Shiba7, Akiko M Saito2, Akio Tawa8, Akira Shimada9, Shotaro Iwamoto10, Yasuhide Hayashi11, Takashi Koike12, Keizo Horibe2, Atsushi Manabe13, Shuki Mizutani14, Takashi Taga15, Souichi Adachi16.
Abstract
The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.Entities:
Keywords: acute myeloid leukaemia; childhood; genetic alteration; haematopoietic stem cell transplantation; primary induction failure
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Year: 2019 PMID： 30784060 DOI： 10.1111/bjh.15799
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998