Literature DB >> 30783988

AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.

Reshma Gore1, Maureen S Riedl2, Kelley F Kitto2, Carolyn A Fairbanks2,3,4, Lucy Vulchanova5.   

Abstract

The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional analysis, circuit mapping, and neuromodulation in the enteric nervous system. Studies of AAV-mediated gene transfer to enteric neurons and dorsal root ganglion neurons (DRG) have provided proofs-of-concept for the utility of AAV vectors for genetic manipulations of the intrinsic and extrinsic components of the enteric nervous system. Here we describe a method for AAV-mediated gene transfer to enteric neurons of the descending colon as well as colon-innervating DRG neurons by injection within the intestinal wall (intracolonic injection).

Entities:  

Keywords:  Colon; Dorsal root ganglion; Enteric; Viral vector

Mesh：

Year:  2019        PMID： 30783988      PMCID： PMC7241593          DOI： 10.1007/978-1-4939-9139-6_24

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  20 in total

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Authors:  Julie A Christianson; Richard J Traub; Brian M Davis
Journal:  J Comp Neurol       Date:  2006-01-10       Impact factor: 3.215

Review 2.  Engineering adeno-associated viruses for clinical gene therapy.

Authors:  Melissa A Kotterman; David V Schaffer
Journal:  Nat Rev Genet       Date:  2014-05-20       Impact factor: 53.242

3.  Transient receptor potential vanilloid 1-immunopositive neurons in the mouse are more prevalent within colon afferents compared to skin and muscle afferents.

Authors:  J A Christianson; S L McIlwrath; H R Koerber; B M Davis
Journal:  Neuroscience       Date:  2006-03-29       Impact factor: 3.590

4.  Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon.

Authors:  J H La; E S Schwartz; G F Gebhart
Journal:  Neuroscience       Date:  2011-04-30       Impact factor: 3.590

5.  Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression.

Authors:  D J Schuster; J A Dykstra; M S Riedl; K F Kitto; C N Honda; R S McIvor; C A Fairbanks; L Vulchanova
Journal:  Neurogastroenterol Motil       Date:  2012-12-18       Impact factor: 3.598

6.  Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture.

Authors:  Lucy Vulchanova; Daniel J Schuster; Lalitha R Belur; Maureen S Riedl; Kelly M Podetz-Pedersen; Kelley F Kitto; George L Wilcox; R Scott McIvor; Carolyn A Fairbanks
Journal:  Mol Pain       Date:  2010-05-28       Impact factor: 3.395

7.  Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse.

Authors:  Daniel J Schuster; Jaclyn A Dykstra; Maureen S Riedl; Kelley F Kitto; Lalitha R Belur; R Scott McIvor; Robert P Elde; Carolyn A Fairbanks; Lucy Vulchanova
Journal:  Front Neuroanat       Date:  2014-06-10       Impact factor: 3.856

8.  Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants.

Authors:  Matthew J Benskey; Nathan C Kuhn; James J Galligan; Joanna Garcia; Shannon E Boye; William W Hauswirth; Christian Mueller; Sanford L Boye; Fredric P Manfredsson
Journal:  Mol Ther       Date:  2015-01-16       Impact factor: 11.454

9.  Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques.

Authors:  S E Gombash; C J Cowley; J A Fitzgerald; C A Lepak; M G Neides; K Hook; L J Todd; G-D Wang; C Mueller; B K Kaspar; E C Bielefeld; A J Fischer; J D Wood; K D Foust
Journal:  Gene Ther       Date:  2017-08-03       Impact factor: 5.250

10.  Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.

Authors:  Ken Y Chan; Min J Jang; Bryan B Yoo; Alon Greenbaum; Namita Ravi; Wei-Li Wu; Luis Sánchez-Guardado; Carlos Lois; Sarkis K Mazmanian; Benjamin E Deverman; Viviana Gradinaru
Journal:  Nat Neurosci       Date:  2017-06-26       Impact factor: 24.884
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  2 in total

1.  Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.

Authors:  Xinhong Chen; Sripriya Ravindra Kumar; Cameron D Adams; Daping Yang; Tongtong Wang; Damien A Wolfe; Cynthia M Arokiaraj; Victoria Ngo; Lillian J Campos; Jessica A Griffiths; Takako Ichiki; Sarkis K Mazmanian; Peregrine B Osborne; Janet R Keast; Cory T Miller; Andrew S Fox; Isaac M Chiu; Viviana Gradinaru
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2.  Targeting the somatosensory system with AAV9 and AAV2retro viral vectors.

Authors:  Alexander G J Skorput; Reshma Gore; Rachel Schorn; Maureen S Riedl; Ezequiel Marron Fernandez de Velasco; Bailey Hadlich; Kelley F Kitto; Carolyn A Fairbanks; Lucy Vulchanova
Journal:  PLoS One       Date:  2022-03-10       Impact factor: 3.240
  2 in total

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