Literature DB >> 30783985

AAV-Mediated Gene Delivery to the Lung.

Laura P van Lieshout1, Jakob M Domm1, Sarah K Wootton2.   

Abstract

Adeno-associated virus (AAV) vectors are an efficient method of gene delivery to various tissues including the lung. Mouse models are often used as a preliminary preclinical model in order to advance AAV lung gene therapy vectors. In this chapter we describe an AAV purification protocol using heparin affinity chromatography as well as an intranasal and intratracheal method of delivering AAV vectors to the lungs of mice.

Entities:  

Keywords:  AAV; AAV purification; AAV6.2FF; Adeno-associated virus; Heparin column chromatography; Intranasal instillation; Lung delivery; Lung gene therapy; Lung gene transfer

Mesh：

Year:  2019        PMID： 30783985     DOI： 10.1007/978-1-4939-9139-6_21

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma.

Authors:  Darrick L Yu; Ashley A Stegelmeier; Byram W Bridle; James J Petrik; Sarah K Wootton; Natalie Chow; Amira D Rghei; Kathy Matuszewska; Jack Lawler
Journal:  Cancer Gene Ther       Date:  2019-06-04       Impact factor: 5.987

2.  AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge.

Authors:  Matthew M Guilleman; Brenna A Y Stevens; Laura P Van Lieshout; Amira D Rghei; Yanlong Pei; Lisa A Santry; Brad Thompson; Sarah K Wootton
Journal:  Gene Ther       Date:  2021-02-19       Impact factor: 5.250

3.  Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep.

Authors:  Amira D Rghei; Laura P van Lieshout; Wenguang Cao; Shihua He; Kevin Tierney; Jordyn A Lopes; Nicole Zielinska; Enzo M Baracuhy; Elena S B Campbell; Jessica A Minott; Matthew M Guilleman; Pamela C Hasson; Brad Thompson; Khalil Karimi; Byram W Bridle; Leonardo Susta; Xiangguo Qiu; Logan Banadyga; Sarah K Wootton
Journal:  Gene Ther       Date:  2022-09-01       Impact factor: 4.184

4.  GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation.

Authors:  Ying Li; Fengxia Ding; Yaping Wang; Kou Liao; Bo Liu; Chao Niu; Wenjing Zou; Lili Yang; Ting Wang; Daiyin Tian; Zhengxiu Luo; Jihong Dai; Qubei Li; Enmei Liu; Caihui Gong; Zhou Fu
Journal:  Respir Res       Date:  2021-02-08

5.  AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma.

Authors:  Ashley A Stegelmeier; Lisa A Santry; Matthew M Guilleman; Kathy Matuszewska; Jessica A Minott; Jacob G E Yates; Brenna A Y Stevens; Sylvia P Thomas; Sierra Vanderkamp; Kiersten Hanada; Yanlong Pei; Amira D Rghei; Jacob P van Vloten; Madison Pereira; Brad Thompson; Pierre P Major; James J Petrik; Byram W Bridle; Sarah K Wootton
Journal:  Biomedicines       Date:  2022-02-02

6.  AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge.

Authors:  Laura P van Lieshout; Amira D Rghei; Wenguang Cao; Shihua He; Geoff Soule; Wenjun Zhu; Sylvia P Thomas; Debra Sorensen; Kathy Frost; Kevin Tierney; Brad Thompson; Stephanie Booth; David Safronetz; Raveendra R Kulkarni; Byram W Bridle; Xiangguo Qiu; Logan Banadyga; Sarah K Wootton
Journal:  Mol Ther Methods Clin Dev       Date:  2022-08-12       Impact factor: 5.849

7.  A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens.

Authors:  Ebony N Gary; Bryce M Warner; Elizabeth M Parzych; Bryan D Griffin; Xizhou Zhu; Nikesh Tailor; Nicholas J Tursi; Mable Chan; Mansi Purwar; Robert Vendramelli; Jihae Choi; Kathy L Frost; Sophia Reeder; Kevin Liaw; Edgar Tello; Ali R Ali; Kun Yun; Yanlong Pei; Sylvia P Thomas; Amira D Rghei; Matthew M Guilleman; Kar Muthumani; Trevor Smith; Sarah K Wootton; Ami Patel; David B Weiner; Darwyn Kobasa
Journal:  iScience       Date:  2021-06-08

8.  Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis.

Authors:  Qingsong Sun; Man Luo; Zhiwei Gao; Xiang Han; Weiqin Wu; Hongmei Zhao
Journal:  BMC Pulm Med       Date:  2021-07-14       Impact factor: 3.317

9.  JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-mediated Transgene Expression in the Lung and Liver of Mice.

Authors:  Darrick L Yu; Natalie Chow; Sarah K Wootton
Journal:  Viruses       Date:  2020-11-06       Impact factor: 5.048

10.  A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency.

Authors:  Laura P van Lieshout; Liqun Xu; Martin H Kang; Jakob M Domm; Arul Vadivel; Laurent Renesme; Christian Mühlfeld; Maria Hurskainen; Ivana Mižíková; Yanlong Pei; Jacob P van Vloten; Sylvia P Thomas; Claudia Milazzo; Chanèle Cyr-Depauw; Jeffrey A Whitsett; Lawrence M Nogee; Sarah K Wootton; Bernard Thébaud
Journal:  Nat Commun       Date:  2020-08-06       Impact factor: 14.919
  10 in total

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