| Literature DB >> 30779917 |
Ma Yanchun1, Wang Yi1, Wang Lu1, Qian Yu1, Yang Jian1, Kong Pengzhou1, Yan Ting1, Li Hongyi1, Wang Fang1, Cheng Xiaolong1, Cui Yongping2.
Abstract
Triptolide, the component of traditional Chinese herb, has been used as an inflammatory medicine and reported to be anti-tumor for various cancers recently. However, the effect of triptolide on Esophageal Squamous Cell Cancer (ESCC) has not yet been elucidated. In the study, we found that triptolide significantly inhibited cell proliferation, invasion, migration and survivability of ESCC cells. Moreover, we observed that triptolide induced ESCC cell cycle arrest at the G1/S phase and apoptosis through cyclin D1-CDK4/6 regulation and caspases activation. In addition, we revealed that triptolide regulates cell apoptosis and metastasis by p53 and mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, respectively. Meanwhile, the inhibitory effect of triptolide on ESCC was validated in mouse xenograft model. So, we propose that triptolide may be a candidate drug for ESCC.Entities:
Keywords: ESCC; MAPK/ERK pathway; Metastasis; Proliferation; Triptolide
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Year: 2019 PMID： 30779917 DOI： 10.1016/j.ejphar.2019.02.030
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432