Literature DB >> 30779584

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria.

Xiao Liang1, Danmeng Luo1, Jia-Lei Yan2, Mohammad A Rezaei1,3, Lilibeth A Salvador-Reyes4, Sarath P Gunasekera5, Chenglong Li1, Tao Ye2,6, Valerie J Paul5, Hendrik Luesch1.   

Abstract

CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry. The total synthesis was achieved by solid-phase method. After screening two biological target libraries, 1 was identified as a selective CXCR7 agonist. The selective activation of CXCR7 by 1 could provide the basis for developing CXCR7-targeted therapeutics and deciphering the role of CXCR7 in different diseases.

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Year:  2019        PMID： 30779584      PMCID： PMC7327960          DOI： 10.1021/acs.orglett.9b00163

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  22 in total

1.  The Protein Data Bank.

Authors:  H M Berman; J Westbrook; Z Feng; G Gilliland; T N Bhat; H Weissig; I N Shindyalov; P E Bourne
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

Authors:  Nicolas Montpas; Jérôme Cabana; Geneviève St-Onge; Stéphanie Gravel; Geneviève Morin; Tomoko Kuroyanagi; Pierre Lavigne; Nobutaka Fujii; Shinya Oishi; Nikolaus Heveker
Journal:  Biochemistry       Date:  2015-02-11       Impact factor: 3.162

3.  Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.

Authors:  Jian Liu; Wuyan Chen; Yechun Xu; Sumei Ren; Wei Zhang; Yingxia Li
Journal:  Bioorg Med Chem       Date:  2015-03-20       Impact factor: 3.641

4.  Five chemically rich species of tropical marine cyanobacteria of the genus Okeania gen. nov. (Oscillatoriales, Cyanoprokaryota).

Authors:  Niclas Engene; Valerie J Paul; Tara Byrum; William H Gerwick; Andrea Thor; Mark H Ellisman
Journal:  J Phycol       Date:  2013-10-21       Impact factor: 2.923

5.  Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing.

Authors:  Weijing Cai; Lilibeth A Salvador-Reyes; Wei Zhang; Qi-Yin Chen; Susan Matthew; Ranjala Ratnayake; Soo Jung Seo; Simon Dolles; Daniel J Gibson; Valerie J Paul; Hendrik Luesch
Journal:  ACS Chem Biol       Date:  2017-12-05       Impact factor: 5.100

6.  Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.

Authors:  Shaoyong Lu; Jian Zhang
Journal:  J Med Chem       Date:  2018-02-26       Impact factor: 7.446

7.  CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.

Authors:  Angélique Levoye; Karl Balabanian; Françoise Baleux; Françoise Bachelerie; Bernard Lagane
Journal:  Blood       Date:  2009-04-20       Impact factor: 22.113

Review 8.  Drug Design Targeting the CXCR4/CXCR7/CXCL12 Pathway.

Authors:  Dongsheng Xu; Rongshi Li; Jianguo Wu; Li Jiang; Haizhen A Zhong
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

9.  Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.

Authors:  Fatma H Al-Awadhi; Bowen Gao; Mohammad A Rezaei; Jason C Kwan; Chenglong Li; Tao Ye; Valerie J Paul; Hendrik Luesch
Journal:  J Med Chem       Date:  2018-07-17       Impact factor: 7.446

10.  Pharmacogenomics of GPCR Drug Targets.

Authors:  Alexander S Hauser; Sreenivas Chavali; Ikuo Masuho; Leonie J Jahn; Kirill A Martemyanov; David E Gloriam; M Madan Babu
Journal:  Cell       Date:  2017-12-14       Impact factor: 41.582
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  4 in total

Review 1.  Advances in exploring the therapeutic potential of marine natural products.

Authors:  Xiao Liang; Danmeng Luo; Hendrik Luesch
Journal:  Pharmacol Res       Date:  2019-07-25       Impact factor: 7.658

2.  Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets.

Authors:  Nicholas G Paciaroni; Verrill M Norwood; Ranjala Ratnayake; Hendrik Luesch; Robert W Huigens
Journal:  Bioorg Med Chem       Date:  2020-05-07       Impact factor: 3.641

Review 3.  Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach.

Authors:  David E Williams; Raymond J Andersen
Journal:  Nat Prod Rep       Date:  2019-11-21       Impact factor: 13.423

4.  GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge Stylissa sp. Extends Its Therapeutic Potential for Noncommunicable Diseases.

Authors:  Harmie Luyao; Hendrik Luesch; Mylene Uy
Journal:  Molecules       Date:  2021-09-16       Impact factor: 4.411
  4 in total

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