| Literature DB >> 30779342 |
Monireh Khordadmehr1, Roya Shahbazi1, Sanam Sadreddini2, Behzad Baradaran2,3.
Abstract
microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19-22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR-193 family comprising miR-193a-3p, miR-193a-5p, miR-193b-3p, and miR-193b-5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.Entities:
Keywords: cancer; downregulation; miR-193; overexpression; target
Mesh:
Substances:
Year: 2019 PMID: 30779342 DOI: 10.1002/jcp.28368
Source DB: PubMed Journal: J Cell Physiol ISSN: 0021-9541 Impact factor: 6.384