Literature DB >> 30779342

miR-193: A new weapon against cancer.

Monireh Khordadmehr1, Roya Shahbazi1, Sanam Sadreddini2, Behzad Baradaran2,3.   

Abstract

microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19-22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogenesis as well as disease formation and progression importantly in cancer cell invasion, migration, and metastasis. Among these notable tiny molecules, many studies recently presented the important role of the miR-193 family comprising miR-193a-3p, miR-193a-5p, miR-193b-3p, and miR-193b-5p in health and disease biological processes by interaction with special targeting and signaling, which mainly contribute as a tumor suppressor. Therefore, in the present paper, we review the functional role of this miRNA family in both health and disease conditions focusing on various tumor developments, diagnoses, prognoses, and treatment.
© 2019 Wiley Periodicals, Inc.

Entities:  

Keywords:  cancer; downregulation; miR-193; overexpression; target

Mesh:

Substances:

Year:  2019        PMID: 30779342     DOI: 10.1002/jcp.28368

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN: 0021-9541            Impact factor:   6.384


  22 in total

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5.  Effect of diabetes on exosomal miRNA profile in patients with obesity.

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6.  LncRNA TUG1 Regulates Cell Viability and Death by Regulating miR-193a-5p/Rab10 Axis in Acute Myeloid Leukemia.

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7.  miR-193b Increases the Chemosensitivity of Osteosarcoma Cells by Promoting FEN1-Mediated Autophagy.

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Journal:  Onco Targets Ther       Date:  2019-11-22       Impact factor: 4.147

8.  Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL.

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Journal:  Mol Ther Nucleic Acids       Date:  2021-04-20       Impact factor: 8.886

9.  Downregulation of miR-193a-3p is involved in the pathogenesis of hepatocellular carcinoma by targeting CCND1.

Authors:  Shi-Shuo Wang; Zhi-Guang Huang; Hua-Yu Wu; Rong-Quan He; Li-Hua Yang; Zhen-Bo Feng; Yi-Wu Dang; Hui-Ping Lu; Ye-Ying Fang; Gang Chen
Journal:  PeerJ       Date:  2020-02-10       Impact factor: 2.984

10.  The Significance of MicroRNAs Expression in Regulation of Extracellular Matrix and Other Drug Resistant Genes in Drug Resistant Ovarian Cancer Cell Lines.

Authors:  Dominika Kazmierczak; Karol Jopek; Karolina Sterzynska; Barbara Ginter-Matuszewska; Michal Nowicki; Marcin Rucinski; Radoslaw Januchowski
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