Davide Viggiano1, Natale G De Santo2, Nagoth Joseph Amruthraj3, Giovanna Capolongo3, Giovambattista Capasso3,4, Pietro Anastasio3. 1. Division of Nephrology, Department of Scienze mediche traslazionali, Università della Campania "L. Vanvitelli", Padiglione 17, via Pansini 5, 80131, Naples, Italy. davide.viggiano@unimol.it. 2. Università della Campania "L. Vanvitelli", Naples, Italy. 3. Division of Nephrology, Department of Scienze mediche traslazionali, Università della Campania "L. Vanvitelli", Padiglione 17, via Pansini 5, 80131, Naples, Italy. 4. Biogem Scarl, Istituto di Ricerche Gaetano Salvatore, Ariano Irpino, Italy.
Abstract
AIM: Different factors have been hypothesized to play a role in the cascade of events associated with the protein-induced glomerular response. However, scant data are available on the possible functional effect of vasopressin (VP) on the glomerular filtration rate (GFR) in humans with central diabetes insipidus (CDI), which was the aim of the present study. METHOD: Renal function was studied under fasting conditions (baseline) and after a meat meal in 16 patients with CDI before and after treatment with desmopressin (DDAVP) and in 16 control subjects. GFR was measured by the inulin method. RESULTS: At baseline, the GFR was lower in patients with CDI. Treatment with DDAVP resulted in an insignificant increase in GFR, which was not statistically different from untreated patients. After an acute oral protein load, the GFR increased, peaking at 45 min post meal in controls, and at 135 min post meal in treated and untreated CDI patients. CONCLUSION: After a meat meal, the peak GFR response is delayed in CDI patients suggesting that VP might indirectly affect tubule-glomerular feedback.
AIM: Different factors have been hypothesized to play a role in the cascade of events associated with the protein-induced glomerular response. However, scant data are available on the possible functional effect of vasopressin (VP) on the glomerular filtration rate (GFR) in humans with central diabetes insipidus (CDI), which was the aim of the present study. METHOD: Renal function was studied under fasting conditions (baseline) and after a meat meal in 16 patients with CDI before and after treatment with desmopressin (DDAVP) and in 16 control subjects. GFR was measured by the inulin method. RESULTS: At baseline, the GFR was lower in patients with CDI. Treatment with DDAVP resulted in an insignificant increase in GFR, which was not statistically different from untreated patients. After an acute oral protein load, the GFR increased, peaking at 45 min post meal in controls, and at 135 min post meal in treated and untreated CDI patients. CONCLUSION: After a meat meal, the peak GFR response is delayed in CDI patients suggesting that VP might indirectly affect tubule-glomerular feedback.
Authors: Susan J Kelly; Marielle Delnomdedieu; Michael I Oliverio; L David Williams; Mark G P Saifer; Merry R Sherman; Thomas M Coffman; G Allan Johnson; Michael S Hershfield Journal: J Am Soc Nephrol Date: 2001-05 Impact factor: 10.121
Authors: P Bardoux; H Martin; M Ahloulay; F Schmitt; N Bouby; M M Trinh-Trang-Tan; L Bankir Journal: Proc Natl Acad Sci U S A Date: 1999-08-31 Impact factor: 11.205